Collaboration and License Agreements - Reduction in Expenses (Details) - Collaborative Arrangement - Roche, Collaboration (Pralsetnib) Agreement - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Collaboration Agreements
Collaborative arrangement, commercialization, reduction in selling, general and administrative expenses	$ 16,600	$ 18,753	$ 10,631
Collaborative arrangement, global development activities, reductions to (increases in) research and development expenses	$ (19,297)	$ 11,192	$ 20,459

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