Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Common Stock Follow-on Public Offering and At-the-market Offering	Common Stock Private Placement	Common Stock	Additional Paid-In Capital Follow-on Public Offering and At-the-market Offering	Additional Paid-In Capital Private Placement	Additional Paid-In Capital	Accumulated Other Comprehensive Loss	Accumulated Deficit	Follow-on Public Offering and At-the-market Offering	Private Placement	Total
Beginning Balance at Dec. 31, 2019			$ 49			$ 1,412,082	$ (2,534)	$ (945,238)			$ 464,359
Beginning Balance (in shares) at Dec. 31, 2019			49,272,223
Increase (Decrease) in Stockholders' Equity
Issuance of common stock under stock plan			$ 1			33,282					33,283
Issuance of common stock under stock plan (in shares)			952,205
Purchase of common stock under ESPP			$ 1			2,153					$ 2,154
Purchase of common stock under ESPP (in shares)			38,516								38,516
Stock-based compensation expense						76,602					$ 76,602
Issuance of common stock	$ 6	$ 1		$ 503,176	$ 79,305				$ 503,182	$ 79,306
Issuance of common stock (in shares)	6,495,070	1,035,519
Other comprehensive income (loss)							(2,680)				(2,680)
Net income (loss)								313,882			313,882
Ending Balance at Dec. 31, 2020			$ 58			2,106,600	(5,214)	(631,356)			1,470,088
Ending Balance (in shares) at Dec. 31, 2020			57,793,533
Increase (Decrease) in Stockholders' Equity
Issuance of common stock under stock plan			$ 1			47,302					47,303
Issuance of common stock under stock plan (in shares)			1,304,386
Purchase of common stock under ESPP						3,313					$ 3,313
Purchase of common stock under ESPP (in shares)			43,167								43,167
Stock-based compensation expense						93,035					$ 93,035
Other comprehensive income (loss)							1,081				1,081
Net income (loss)								(644,085)			(644,085)
Ending Balance at Dec. 31, 2021			$ 59			2,250,250	(4,133)	(1,275,441)			$ 970,735
Ending Balance (in shares) at Dec. 31, 2021			59,141,086								59,141,086
Increase (Decrease) in Stockholders' Equity
Issuance of common stock under stock plan			$ 1			4,610					$ 4,611
Issuance of common stock under stock plan (in shares)			737,116
Purchase of common stock under ESPP						3,524					$ 3,524
Purchase of common stock under ESPP (in shares)			80,717								80,717
Stock-based compensation expense						99,634					$ 99,634
Other comprehensive income (loss)							(6,310)				(6,310)
Net income (loss)								(557,517)			(557,517)
Ending Balance at Dec. 31, 2022			$ 60			$ 2,358,018	$ (10,443)	$ (1,832,958)			$ 514,677
Ending Balance (in shares) at Dec. 31, 2022			59,958,919								59,958,919