Collaboration and License Agreements - Reduction in Expenses (Details) - Collaborative Arrangement - Roche, Collaboration (Pralsetnib) Agreement - USD ($) $ in Thousands	3 Months Ended	9 Months Ended
Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Collaboration Agreements
Collaborative arrangement, commercialization, reduction in selling, general and administrative expenses	$ 6,903	$ 5,317	$ 12,058	$ 5,317
Collaborative arrangement, global development activities, reduction in research and development expenses	$ 1,459	$ 9,715	$ 7,613	$ 9,715

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