As filed with the Securities and Exchange Commission on March 9,  2017

Registration No. 333-        

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM S-8

REGISTRATION STATEMENT

UNDER THE

SECURITIES ACT OF 1933

Blueprint Medicines Corporation

(Exact name of registrant as specified in its charter)

Delaware	26-3632015
(State or other jurisdiction of incorporation)	(I.R.S. Employer Identification No.)
38 Sidney Street, Suite 200 Cambridge, Massachusetts	02139
(Address of principal executive offices)	(Zip Code)

2015 Stock Option and Incentive Plan

2015 Employee Stock Purchase Plan

(Full titles of the plans)

Jeffrey W. Albers

President and Chief Executive Officer

Blueprint Medicines Corporation

38 Sidney Street, Suite 200

Cambridge, Massachusetts 02139

(Name and address of agent for service)

(617) 374-7580 

(Telephone number, including area code, of agent for service)

Please send copies of all communications to:

Kingsley L. Taft, Esq.

Danielle M. Lauzon, Esq.

Goodwin Procter LLP

100 Northern Avenue

Boston, Massachusetts 02210

(617) 570-1000

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer	☐	Accelerated filer	☒
Non-accelerated filer	☐ (Do not check if a smaller reporting company)	Smaller reporting company	☐

CALCULATION OF REGISTRATION FEE

Title of Securities to be Registered	Amount to be Registered (1)	Proposed Maximum Offering Price Per Share		Proposed Maximum Aggregate Offering Price		Amount of Registration Fee
Common Stock, $0.001 par value per share	1,325,019	$ 35.03	(2)	$ 46,415,415.57	(2)	$ 5,379.55
Common Stock, $0.001 par value per share	331,254	$ 29.78	(3)	$ 9,864,744.12	(3)	$ 1,143.33
Total	1,656,273			$ 56,280,159.69		$ 6,522.88

(1) In accordance with Rule 416 under the Securities Act of 1933, as amended (the “Securities Act”), this registration statement shall be deemed to cover any additional shares of common stock that may from time to time be offered or issued under the above-named plans to prevent dilution resulting from stock splits, stock dividends, recapitalizations or similar transactions effected without the receipt of consideration which results in an increase in the number of the Registrant’s outstanding shares of Common Stock. Pursuant to Rule 416(c) under the Securities Act, this Registration Statement shall also cover an indeterminate amount of interests to be offered or sold pursuant to the employee benefit plans described herein.

(2) Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) of the Securities Act and based upon the average of the high and low prices of the Registrant’s Common Stock as reported on The NASDAQ Global Select Market on March 2,  2017.

(3) Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) of the Securities Act and based upon the average of the high and low prices of the Registrant’s Common Stock as reported on The NASDAQ Global Select Market on March 2,  2017, multiplied by 85%, which is the percentage of the price per share applicable to purchasers under the 2015 Employee Stock Purchase Plan.

EXPLANATORY NOTE

This Registration Statement on Form S-8 relating to the 2015 Stock Option and Incentive Plan (the “2015 Plan”) and the 2015 Employee Stock Purchase Plan (the “2015 ESPP”) of Blueprint Medicines Corporation (the “Registrant”) is being filed for the purpose of registering additional securities of the same class as other securities for which a Registration Statement on Form S-8 has previously been filed and is effective. Accordingly, this Registration Statement on Form S-8 incorporates by reference the contents of (i) the Registration Statement on Form S-8  (File No. 333-203749)  filed with the Securities and Exchange Commission (the “SEC”) on April 30,  2015 by the Registrant, relating to the 2015 Plan and the 2015 ESPP and (ii) the Registration Statement on Form S-8 (File No. 333-210125)  filed with the SEC on March 11, 2016 by the Registrant, relating to the 2015 Plan and the 2015 ESPP, in each case, except for “Item 8. Exhibits”  with respect to which the Exhibit Index immediately preceding the exhibits attached hereto is incorporated herein by reference.  

SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Cambridge, Commonwealth of Massachusetts, on this 9th day of March, 2017.  

BLUEPRINT MEDICINES CORPORATION
By:	/s/ Jeffrey W. Albers
	Jeffrey W. Albers
	President and Chief Executive Officer

POWER OF ATTORNEY AND SIGNATURES 

We, the undersigned officers and directors of Blueprint Medicines Corporation, hereby severally constitute and appoint Jeffrey W. Albers and Michael Landsittel, and each of them singly, our true and lawful attorneys with full power to any of them, and to each of them singly, to sign for us and in our names in the capacities indicated below the Registration Statement on Form S-8 filed herewith and any and all amendments to said Registration Statement, and generally to do all such things in our name and on our behalf in our capacities as officers and directors to enable Blueprint Medicines Corporation to comply with the provisions of the Securities Act of 1933, as amended, and all requirements of the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said attorneys, or any of them, to said registration statement and any and all amendments thereto.

Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons in the capacities and on the dates indicated.

Signature	Title	Date
/s/ Jeffrey W. Albers	President, Chief Executive Officer and Director	March 9, 2017
Jeffrey W. Albers	(Principal Executive Officer)
/s/ Michael Landsittel	Vice President of Finance	March 9, 2017
Michael Landsittel	(Principal Financial and Accounting Officer)
/s/ Daniel S. Lynch	Chairman of the Board	March 9, 2017
Daniel S. Lynch
/s/ Nicholas Lydon	Director	March 9, 2017
Nicholas Lydon, Ph.D.
/s/ Alexis Borisy	Director	March 9, 2017
Alexis Borisy
/s/ Mark Goldberg	Director	March 9, 2017
Mark Goldberg, M.D.
/s/ Charles A. Rowland, Jr.	Director	March 9, 2017
Charles A. Rowland, Jr.
/s/ George Demetri	Director	March 9, 2017
George Demetri, M.D.
/s/ Lonnel Coats	Director	March 9, 2017
Lonnel Coats
/s/ Lynn Seely	Director	March 9, 2017
Lynn Seely, M.D.

EXHIBIT INDEX

		Incorporated by Reference
Exhibit Number	Description of Exhibit	Form	File No.	Exhibit Number	Filing Date
3.1	Fifth Amended and Restated Certificate of Incorporation of the Registrant	10-Q	001-37359	3.1	November 9, 2015
3.2	Amended and Restated Bylaws of the Registrant	10-Q	001-37359	3.2	November 9, 2015
4.1	Specimen Common Stock Certificate	S-1/A	333-202938	4.1	April 20, 2015
4.2	Second Amended and Restated Investors’ Rights Agreement, dated as of November 7, 2014, by and among the Registrant and the Investors listed therein	S-1	333-202938	4.4	March 23, 2015
5.1	Opinion of Goodwin Procter LLP, counsel to the Registrant				*
23.1	Consent of Ernst & Young LLP, an independent registered public accounting firm				*
23.2	Consent of Goodwin Procter LLP (included in Exhibit 5.1)				*
24.1	Power of attorney (included on the signature pages of this registration statement)				*
99.1	2015 Stock Option and Incentive Plan	10-K	001-37359	10.2	March 11, 2016
99.2	2015 Employee Stock Purchase Plan	S-8	333-203749	99.3	April 30, 2015

*   Filed herewith.