POWER OF ATTORNEY



      The undersigned, as a Section 16 reporting person of Alpine Immune
Sciences, Inc. (the "Company"), hereby constitutes and appoints Paul Rickey,
Nicole Marshall and each of the responsible attorneys and paralegals of
Wilson Sonsini Goodrich & Rosati, Professional Corporation, the undersigned's
true and lawful attorney-in-fact to:

     1.  complete and execute Forms ID, 3,4 and 5 and other forms and all
         amendments thereto as such attorney-in-fact shall in his or her
         discretion determine to be required or advisable pursuant to Section
         16 of the Securities Exchange Act of 1934 (as amended) and the rules
         and regulations promulgated thereunder, or any successor laws and
         regulations, as a consequence of the undersigned's ownership,
         acquisition or disposition of securities of the Company; and

     2.  do all acts necessary in order to file such forms with the Securities
         and Exchange Commission, any securities exchange or national
         association, the Company and such other person or agency as the
         attorney-in-fact shall deem appropriate.

      The undersigned hereby ratifies and confirms all that said
attorneys-in-fact and agents shall do or cause to be done by virtue hereof.  The
undersigned acknowledges that the foregoing attorneys-in-fact, in serving in
such capacity at the request of the undersigned, are not assuming, nor is the
Company assuming, any of the undersigned's responsibilities to comply with
Section 16 of the Securities Exchange Act of 1934 (as amended).

      This Power of Attorney shall remain in full force and effect until the
undersigned is no longer required to file Forms ID, 3, 4 and 5 with respect to
the undersigned's holdings of and transactions in securities issued by the
Company, unless earlier revoked by the undersigned in a signed writing
delivered to the Company and the foregoing attorneys-in-fact.


       IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to
be executed as of May 24, 2022.


                                         Signature:  /s/ Andrew Sandler, MD
                                                     -----------------------
                                                     Andrew Sandler MD