0001493152-24-032150.txt : 20240814 0001493152-24-032150.hdr.sgml : 20240814 20240814160527 ACCESSION NUMBER: 0001493152-24-032150 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20240630 FILED AS OF DATE: 20240814 DATE AS OF CHANGE: 20240814 EFFECTIVENESS DATE: 20240814 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Opaleye Management Inc. CENTRAL INDEX KEY: 0001595855 ORGANIZATION NAME: IRS NUMBER: 205648796 STATE OF INCORPORATION: MA FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15896 FILM NUMBER: 241207490 BUSINESS ADDRESS: STREET 1: ONE BOSTON PLACE STREET 2: SUITE 2600 CITY: BOSTON STATE: MA ZIP: 02108 BUSINESS PHONE: 617-904-9195 MAIL ADDRESS: STREET 1: ONE BOSTON PLACE STREET 2: SUITE 2600 CITY: BOSTON STATE: MA ZIP: 02108 13F-HR 1 primary_doc.xml X0202 13F-HR LIVE false true false 0001595855 XXXXXXXX 06-30-2024 06-30-2024 false Opaleye Management Inc.

One Boston Place Suite 2600 Boston MA 02108

13F HOLDINGS REPORT 028-15896 000124513 801-78700 N James Silverman 617-229-5085 /s/ James Silverman Boston MA 08-14-2024 0 51 437656641 INFORMATION TABLE 2 infotable.xml 4D MOLECULAR THERAPEUTICS INC COM 35104E100 7257293 345750 SH SOLE 345750 0 0 ABCELLERA BIOLOGICS INC COM 00288U106 592000 200000 SH SOLE 200000 0 0 ACELYRIN INC COM 00445A100 6967800 1580000 SH SOLE 1580000 0 0 AEROVATE THERAPEUTICS INC COM 008064107 730400 440000 SH SOLE 440000 0 0 ALIGOS THERAPEUTICS INC COM 01626L105 441000 1260000 SH SOLE 1260000 0 0 ALLAKOS INC COM 01671P100 2780000 2780000 SH SOLE 2780000 0 0 APPLIED THERAPEUTICS INC' COM 03828A101 7845600 1680000 SH SOLE 1680000 0 0 ARVINAS INC COM 04335A105 14774100 555000 SH SOLE 555000 0 0 BIODESIX INC COM 09075X108 6150600 4020000 SH SOLE 4020000 0 0 CARGO THERAPEUTICS INC COM 14179K101 9124594 555700 SH SOLE 555700 0 0 CATALYST PHARMACEUTICALS INC COM 14888U101 9913600 640000 SH SOLE 640000 0 0 CODEXIS INC COM 192005106 10710500 3455000 SH SOLE 3455000 0 0 CYTOKINETICS INC COM NEW 23282W605 10754730 198500 SH SOLE 198500 0 0 DESIGN THERAPEUTICS INC COM 25056L103 686750 205000 SH SOLE 205000 0 0 EDGEWISE THERAPEUTICS INC COM 28036F105 10445800 580000 SH SOLE 580000 0 0 ETON PHARMACEUTICALS INC COM 29772L108 7879550 2395000 SH SOLE 2395000 0 0 FULCRUM THERAPEUTICS INC COM 359616109 1767000 285000 SH SOLE 285000 0 0 GOSSAMER BIO INC COM 38341P102 3522519 3910000 SH SOLE 3910000 0 0 GOSSAMER BIO INC NOTE 5.000% 6/0 38341PAA0 3957752 8000000 PRN SOLE 8000000 0 0 HARROW HEALTH INC COM 415858109 83351100 3990000 SH SOLE 3990000 0 0 IBIO INC COM NEW 451033708 791250 375000 SH SOLE 375000 0 0 IMMUNOME INC COM 45257U108 13340250 1102500 SH SOLE 1102500 0 0 INTELLIA THERAPEUTICS INC COM 45826J105 4878840 218000 SH SOLE 218000 0 0 IOVANCE BIOTHERAPEUTICS INC COM 462260100 7193940 897000 SH SOLE 897000 0 0 JASPER THERAPEUTICS INC COM NEW 471871202 8898400 392000 SH SOLE 392000 0 0 KARYOPHARM THERAPEUTICS INC NOTE 3.000%10/1 48576UAA4 3747156 6000000 PRN SOLE 6000000 0 0 KARYOPHARM THERAPEUTICS INC COM 48576U106 1236330 1425000 SH SOLE 1425000 0 0 KEROS THERAPEUTICS INC COM 492327101 16794750 367500 SH SOLE 367500 0 0 LEXICON PHARMACEUTICALS INC COM NEW 528872302 3150000 1875000 SH SOLE 1875000 0 0 LIQUIDIA CORPORATION COM NEW 53635D202 3900000 325000 SH SOLE 325000 0 0 LYELL IMMUNOPHARMA INC COM 55083R104 2421500 1670000 SH SOLE 1670000 0 0 NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES N62509109 6051150 315000 SH SOLE 315000 0 0 NURIX THERAPEUTICS INC COM 67080M103 8743027 418928 SH SOLE 418928 0 0 NUVALENT INC COM 670703107 4498498 59300 SH SOLE 59300 0 0 OCULAR THERAPEUTIX INC COM 67576A100 36303300 5307500 SH SOLE 5307500 0 0 PMV PHARMACEUTICALS INC COM 69353Y103 769500 475000 SH SOLE 475000 0 0 PROTAGONIST THERAPEUTICS INC COM 74366E102 3638250 105000 SH SOLE 105000 0 0 PROTARA THERAPEUTICS INC COM STK 74365U107 5299803 2304262 SH SOLE 2304262 0 0 REGULUS THERAPEUTICS INC COM 75915K309 2632875 1475000 SH SOLE 1475000 0 0 RELMADA THERAPEUTICS INC COM 75955J402 1800000 600000 SH SOLE 600000 0 0 RENEO PHARMACEUTICALS INC COM 75974E103 249150 165000 SH SOLE 165000 0 0 RHYTHM PHARMACEUTICALS INC COM 76243J105 21145900 515000 SH SOLE 515000 0 0 SAVARA INC COM 805111101 2881289 714960 SH SOLE 714960 0 0 SYROS PHARMACEUTICALS INC COM NEW 87184Q206 4465686 865443 SH SOLE 865443 0 0 TG THERAPEUTICS INC COM 88322Q108 40561200 2280000 SH SOLE 2280000 0 0 TREVI THERAPEUTICS INC COM 89532M101 7882100 2645000 SH SOLE 2645000 0 0 UROGEN PHARMA LTD COM M96088105 6913360 412000 SH SOLE 412000 0 0 VAXCYTE INC COM 92243G108 6418350 85000 SH SOLE 85000 0 0 VENTYX BIOSCIENCES INC COM 92332V107 2748900 1190000 SH SOLE 1190000 0 0 VERASTEM INC COM NEW 92337C203 2726700 915000 SH SOLE 915000 0 0 XOMA CORP DEL COM NEW 98419J206 5922500 250000 SH SOLE 250000 0 0