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Stock-based Compensation - Stock-Based Compensation Expense (Detail) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Stock-based compensation expense $ 10,800 $ 9,920
Research and Development Expense [Member]    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Stock-based compensation expense 5,670 5,031
General and Administrative Expense [Member]    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Stock-based compensation expense $ 5,130 $ 4,889