Income Taxes - Components of Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Deferred tax assets:
Net operating loss carryforwards	$ 61,929	$ 25,435
Research and development tax credits	77,178	62,545
Stock-based compensation	22,405	21,770
Lease liabilities	24,671	27,085
Liability related sale of future royalties	22,482	35,711
Capitalized research and development costs	107,302	74,989
Accruals and other	7,785	11,673
Total deferred tax assets before valuation allowance	323,752	259,208
Valuation allowance	(280,455)	(211,150)
Total deferred tax assets	43,297	48,058
Deferred tax liabilities:
Right-of-use assets	(16,523)	(18,571)
Depreciation and amortization	(26,774)	(29,487)
Total deferred tax liabilities	$ (43,297)	$ (48,058)