License and Collaboration Agreements -Schedule of AbbVie Collaboration Agreement (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
License Revenue [Line Items]
Total license and royalty revenue	$ 112,724,000	$ 470,347,000	$ 154,567,000
Net cost reimbursement to (from) AbbVie included in:
Total net cost reimbursement to (from) AbbVie	(17,763)	(5,866)
Abb Vie Collaboration And License Agreement
License Revenue [Line Items]
Total license and royalty revenue		370,000
Abb Vie Collaboration And License Agreement | Research and Development Expense [Member]
Net cost reimbursement to (from) AbbVie included in:
Total net cost reimbursement to (from) AbbVie	(19,294)	$ (5,866)
Abb Vie Collaboration And License Agreement | General and Administrative Expense [Member]
Net cost reimbursement to (from) AbbVie included in:
Total net cost reimbursement to (from) AbbVie	$ 1,531