Expenses by nature - Operating expenses excluding expenses presented in other expenses (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Operating expenses:
Employee-related expenses	$ 119,903	$ 96,161	$ 75,926
Laboratory and development expenses	65,964	36,014	35,977
Office and housing expenses	17,612	14,638	13,388
Legal and advisory expenses	15,782	24,767	17,370
Other operating expenses	8,510	10,528	8,772
Patent and license expenses	9,548	3,748	2,899
Depreciation and amortization expenses	8,250	7,299	10,648
Fair value loss - Corlieve contingent consideration	7,081	6,683
Total	$ 252,650	$ 199,838	$ 164,980