CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY - USD ($) $ in Thousands	Ordinary shares	Additional paid-in capital	Accumulated other comprehensive income (loss)	Accumulated deficit	Total
Beginning balance at Dec. 31, 2020	$ 2,711	$ 1,016,018	$ 9,907	$ (784,731)	$ 243,905
Beginning balance (in shares) at Dec. 31, 2020	44,777,799
Increase (decrease) in shareholders' equity
Loss for the period				(41,556)	(41,556)
Other comprehensive loss			(7,560)		(7,560)
Issuance of ordinary shares	$ 52	27,647			27,699
Issuance of ordinary shares (in shares)	859,885
Exercise of share options	$ 1	391			392
Exercise of share options (in shares)	16,782
Restricted share units distributed during the period	$ 16	(16)
Restricted share units distributed during the period (in shares)	269,089
Share-based compensation expense		5,761			5,761
Issuance of ordinary shares relating to employee stock purchase plan		49			49
Issuance of ordinary shares relating to employee stock purchase plan (in shares)	1,174
Ending balance at Mar. 31, 2021	$ 2,780	1,049,850	2,347	(826,287)	228,690
Ending balance (in shares) at Mar. 31, 2021	45,924,729
Beginning balance at Dec. 31, 2021	$ 2,802	1,076,972	(28,856)	(455,142)	$ 595,776
Beginning balance (in shares) at Dec. 31, 2021	46,298,635				46,298,635
Increase (decrease) in shareholders' equity
Loss for the period				(46,678)	$ (46,678)
Other comprehensive loss			(10,450)		(10,450)
Exercise of share options	$ 4	420			424
Exercise of share options (in shares)	68,124
Restricted share units distributed during the period	$ 15	(15)
Restricted share units distributed during the period (in shares)	271,131
Share-based compensation expense		6,868			6,868
Issuance of ordinary shares relating to employee stock purchase plan		61			61
Issuance of ordinary shares relating to employee stock purchase plan (in shares)	3,558
Ending balance at Mar. 31, 2022	$ 2,821	$ 1,084,306	$ (39,306)	$ (501,820)	$ 546,001
Ending balance (in shares) at Mar. 31, 2022	46,641,448				46,641,448