Power of Attorney

	Know all by these presents, that the undersigned hereby makes, constitutes
and appoints each of Iqbal Hussain, Gregory Weinhoff, and Richard Menziuso,
or either of them acting singly, and with full power of substitution
and re-substitution, the undersigned's true and lawful attorney-in-fact
(each of such persons and their substitutes being referred to herein
as the "Attorney-in-Fact"), with full power to act for the undersigned
and in the undersigned's name, place and stead, in any and all capacities, to:
1.	Prepare, execute, and submit to the Securities and Exchange
Commission ("SEC") a Form ID, including amendments thereto, and any other
documents necessary or  appropriate to obtain codes and passwords enabling
the undersigned to make electronic filings with the SEC of reports required
or considered by the Attorney-in-Fact to be advisable under Section 13 or
Section 16 of the Securities Exchange Act of 1934 (the "Exchange Act") or
any rule or regulation of the SEC;
2.	Prepare, execute and submit to the SEC, Centessa Pharmaceuticals plc,
a public limited company organized under the laws of England and
Wales (the "Company"), and/or any national securities exchange on which
the Company's securities are listed any and all reports (including any
amendments thereto) the undersigned is required to file with the SEC,
or which the Attorney-in-Fact considers it  advisable to file with the SEC,
under Section 13 or Section 16 of the Exchange Act or any rule or  regulation
thereunder, or under Rule 144 under the Securities Act of 1933 ("Rule 144"),
with respect to the any security of the Company, including Forms 3, 4 and 5,
Schedules 13D and 13G, and Forms 144; and
3.	Obtain, as the undersigned's representative and on the undersigned's behalf,
information regarding transactions in the Company's equity securities from
any third party, including the Company and any brokers, dealers, employee
benefit plan administrators and trustees, and the undersigned hereby authorizes
any such third party to release any such information to the Attorney-in-Fact.
	The undersigned acknowledges that:
a)	This Power of Attorney authorizes, but does not require, the
Attorney-in-Fact to act in his or her discretion on information provided
to such Attorney-in-Fact without independent verification of such information;
b)	Any documents prepared or executed by the Attorney-in-Fact on behalf
of the undersigned pursuant to this Power of Attorney will be in such form
and will contain such information as the Attorney-in-Fact, in his or
her discretion, deems necessary or desirable;
c)	Neither the Company nor the Attorney-in-Fact assumes any liability
for the undersigned's responsibility to comply with the requirements of
Section 13 or Section 16 of the Exchange Act or Rule 144, any liability
of the undersigned for any failure to comply with such requirements, or
any liability of the undersigned for disgorgement of profits under
Section 16(b) of the Exchange Act; and
d)	This Power of Attorney does not relieve the undersigned from
responsibility for compliance with the undersigned's obligations
under Section 13 or Section 16 of the Exchange Act, including,
without limitation, the reporting requirements under Section 13 or
Section 16 of the Exchange Act.
	The undersigned hereby grants to the Attorney-in-Fact full power
and authority to do and perform each and every act and thing requisite,
necessary or advisable to be done in connection with the foregoing,
as fully, to all intents and purposes, as the undersigned might or could
do in person, hereby ratifying and confirming all that the Attorney-in-Fact,
or his or her substitute or substitutes, shall lawfully do or cause to be
done by authority of this Power of Attorney. The undersigned hereby agrees
to indemnify the attorneys-in-fact and the Company from and against
any demand, damage, loss, cost or expense arising from any false or
misleading information provided by the undersigned to the attorneys-in-fact.
	This Power of Attorney shall remain in full force and effect
until the undersigned is no longer required to file Forms 4 or 5 or
Schedules 13D or 13G or Forms 144 with respect to the undersigned's
holdings of and transactions in securities of the Company, unless earlier
revoked by the undersigned in a signed writing delivered to the
Attorney-in-Fact. This Power of Attorney revokes all previous powers of
attorney with respect to the subject matter of this Power of Attorney.
This Power of Attorney shall expire as to any individual attorney-in-fact
if such attorney-in-fact ceasesto be an employee of the Company.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney
as of June 13, 2024.


/s/ John J. Crowley
Signature

John J. Crowley
Print Name