The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERON PHARMA INC COM 00434H108 410 10,977 SH   OTR   0 10,977 0
ACHILLION PHARMACEUTICALS IN COM 00448Q201 348 77,433 SH   OTR   0 77,433 0
ACORDA THERAPEUTICS INC COM 00484M106 1,419 60,003 SH   OTR   0 60,003 0
ADURO BIOTECH INC COM 00739L101 327 30,685 SH   OTR   0 30,685 0
AGENUS INC COM NEW 00847G705 417 94,517 SH   OTR   0 94,517 0
AGIOS PHARMACEUTICALS INC COM 00847X104 430 6,435 SH   OTR   0 6,435 0
AIMMUNE THERAPEUTICS INC COM 00900T107 444 17,898 SH   OTR   0 17,898 0
AKEBIA THERAPEUTICS INC COM 00972D105 453 23,019 SH   OTR   0 23,019 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 518 4,411 SH   OTR   0 4,411 0
AMICUS THERAPEUTICS INC COM 03152W109 576 38,223 SH   OTR   0 38,223 0
ANDEAVOR LOGISTICS LP COM UNIT LP INT 03350F106 27,887 557,073 SH   OTR   0 557,073 0
ANTERO MIDSTREAM PARTNERS LP UNT LTD PARTN 03673L103 8,021 254,406 SH   OTR   0 254,406 0
AQUINOX PHARMACEUTICALS INC COM 03842B101 339 23,869 SH   OTR   0 23,869 0
ARRAY BIOPHARMA INC COM 04269X105 520 42,236 SH   OTR   0 42,236 0
AVEXIS INC COM 05366U100 448 4,636 SH   OTR   0 4,636 0
AXOVANT SCIENCES LTD COM G0750W104 97 14,151 SH   OTR   0 14,151 0
BEIGENE LTD SPONSORED ADR 07725L102 839 8,113 SH   OTR   0 8,113 0
BIOCRYST PHARMACEUTICALS COM 09058V103 298 56,873 SH   OTR   0 56,873 0
BIOGEN INC COM 09062X103 1,279 4,085 SH   OTR   0 4,085 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 1,048 11,260 SH   OTR   0 11,260 0
BLUEBIRD BIO INC COM 09609G100 404 2,945 SH   OTR   0 2,945 0
BLUEPRINT MEDICINES CORP COM 09627Y109 592 8,495 SH   OTR   0 8,495 0
BUCKEYE PARTNERS L P UNIT LTD PARTN 118230101 48,874 857,445 SH   OTR   0 857,445 0
CALITHERA BIOSCIENCES INC COM 13089P101 367 23,312 SH   OTR   0 23,312 0
CARA THERAPEUTICS INC COM 140755109 259 18,915 SH   OTR   0 18,915 0
CELGENE CORP COM 151020104 1,247 8,551 SH   OTR   0 8,551 0
CELLDEX THERAPEUTICS INC NEW COM 15117B103 400 139,774 SH   OTR   0 139,774 0
CHENIERE ENERGY PARTNERS LP COM UNIT 16411Q101 1,255 43,552 SH   OTR   0 43,552 0
CLOVIS ONCOLOGY INC COM 189464100 1,347 16,349 SH   OTR   0 16,349 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 400 55,909 SH   OTR   0 55,909 0
CRESTWOOD EQUITY PARTNERS LP UNIT LTD PARTNER 226344208 8,163 334,558 SH   OTR   0 334,558 0
CYTOKINETICS INC COM NEW 23282W605 339 23,395 SH   OTR   0 23,395 0
CYTOMX THERAPEUTICS INC COM 23284F105 437 24,077 SH   OTR   0 24,077 0
DCP MIDSTREAM PARTNERS LP COM UT LTD PTN 23311P100 8,082 233,301 SH   OTR   0 233,301 0
DIREXION SHS ETF TR DLY FIN BULL NEW 25459Y694 1,148 20,503 SH   OTR   0 20,503 0
DOMINION MIDSTREAM PARTNERS COM UT REP LTD 257454108 102 3,189 SH   OTR   0 3,189 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 673 31,321 SH   OTR   0 31,321 0
ENANTA PHARMACEUTICALS INC COM 29251M106 1,509 32,235 SH   OTR   0 32,235 0
ENBRIDGE ENERGY PARTNERS L P COM 29250R106 34,157 2,137,474 SH   OTR   0 2,137,474 0
ENBRIDGE INC COM 29250N105 1,457 34,816 SH   OTR   0 34,816 0
ENERGY TRANSFER EQUITY L P COM UT LTD PTN 29273V100 45,178 2,599,426 SH   OTR   0 2,599,426 0
ENERGY TRANSFER EQUITY L P PUT 29273V950 32 7,942 SH Put OTR   0 7,942 0
ENERGY TRANSFER PARTNERS LP UNIT LTD PRT INT 29278N103 93,549 5,114,749 SH   OTR   0 5,114,749 0
ENERGY TRANSFER PARTNERS LP CALL 29278N903 1 100 SH Call OTR   0 100 0
ENLINK MIDSTREAM LLC COM UNIT REP LTD 29336T100 6,285 364,345 SH   OTR   0 364,345 0
ENLINK MIDSTREAM PARTNERS LP COM UNIT REP LTD 29336U107 29,087 1,735,472 SH   OTR   0 1,735,472 0
ENTERPRISE PRODS PARTNERS L COM 293792107 40,195 1,541,809 SH   OTR   0 1,541,809 0
ENTERPRISE PRODS PARTNERS L CALL 293792907 2 300 SH Call OTR   0 300 0
EPIZYME INC COM 29428V104 509 26,709 SH   OTR   0 26,709 0
EQT MIDSTREAM PARTNERS LP UNIT LTD PARTN 26885B100 24,261 323,612 SH   OTR   0 323,612 0
ESPERION THERAPEUTICS INC NE COM 29664W105 464 9,250 SH   OTR   0 9,250 0
EXELIXIS INC COM 30161Q104 1,275 52,621 SH   OTR   0 52,621 0
FIBROGEN INC COM 31572Q808 607 11,278 SH   OTR   0 11,278 0
FIDELITY MSCI FINLS IDX 316092501 1,255 33,040 SH   OTR   0 33,040 0
FIDELITY MSCI INFO TECH I 316092808 2,927 63,417 SH   OTR   0 63,417 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 449 10,966 SH   OTR   0 10,966 0
GENESIS ENERGY L P UNIT LTD PARTN 371927104 13,941 529,074 SH   OTR   0 529,074 0
GERON CORP COM 374163103 273 125,425 SH   OTR   0 125,425 0
GILEAD SCIENCES INC COM 375558103 1,290 15,926 SH   OTR   0 15,926 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 368 11,845 SH   OTR   0 11,845 0
GLYCOMIMETICS INC COM 38000Q102 405 28,961 SH   OTR   0 28,961 0
HALOZYME THERAPEUTICS INC COM 40637H109 1,361 78,354 SH   OTR   0 78,354 0
IGNYTA INC COM 451731103 474 38,356 SH   OTR   0 38,356 0
IMMUNOGEN INC COM 45253H101 536 70,035 SH   OTR   0 70,035 0
IMMUNOMEDICS INC COM 452907108 598 42,784 SH   OTR   0 42,784 0
INCYTE CORP COM 45337C102 1,006 8,619 SH   OTR   0 8,619 0
INOVIO PHARMACEUTICALS INC COM NEW 45773H201 261 41,233 SH   OTR   0 41,233 0
INSMED INC COM PAR $.01 457669307 649 20,798 SH   OTR   0 20,798 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 493 8,501 SH   OTR   0 8,501 0
INTRA CELLULAR THERAPIES INC COM 46116X101 483 30,600 SH   OTR   0 30,600 0
IONIS PHARMACEUTICALS INC COM 462222100 1,033 20,375 SH   OTR   0 20,375 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 423 54,523 SH   OTR   0 54,523 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 920 58,346 SH   OTR   0 58,346 0
ISHARES TR 20 YR TR BD ETF 464287432 610 4,889 SH   OTR   0 4,889 0
ISHARES TR CALL 464287902 25 12,432 SH Call OTR   0 12,432 0
ISHARES TR PUT 464287952 7 1,400 SH Put OTR   0 1,400 0
JOUNCE THERAPEUTICS INC COM 481116101 316 20,298 SH   OTR   0 20,298 0
JPMORGAN CHASE & CO CALL 46625H905 45 9,000 SH Call OTR   0 9,000 0
JUNO THERAPEUTICS INC COM 48205A109 640 14,261 SH   OTR   0 14,261 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 393 35,776 SH   OTR   0 35,776 0
KERYX BIOPHARMACEUTICALS INC COM 492515101 1,115 157,065 SH   OTR   0 157,065 0
KINDER MORGAN INC DEL COM 49456B101 10,851 565,747 SH   OTR   0 565,747 0
KINDER MORGAN INC DEL CALL 49456B901 16 4,000 SH Call OTR   0 4,000 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 412 11,845 SH   OTR   0 11,845 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 239 19,472 SH   OTR   0 19,472 0
LIGAND PHARMACEUTICALS INC COM NEW 53220K504 1,218 8,947 SH   OTR   0 8,947 0
LOXO ONCOLOGY INC COM 548862101 407 4,413 SH   OTR   0 4,413 0
MACROGENICS INC COM 556099109 341 18,449 SH   OTR   0 18,449 0
MAGELLAN MIDSTREAM PRTNRS LP COM UNIT RP LP 559080106 17,494 246,189 SH   OTR   0 246,189 0
MARATHON PETE CORP COM 56585A102 28,525 508,655 SH   OTR   0 508,655 0
MARATHON PETE CORP CALL 56585A902 3 2,885 SH Call OTR   0 2,885 0
MARATHON PETE CORP PUT 56585A952 9 1,607 SH Put OTR   0 1,607 0
MEDICINES CO COM 584688105 1,002 27,060 SH   OTR   0 27,060 0
MINERVA NEUROSCIENCES INC COM 603380106 260 34,183 SH   OTR   0 34,183 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 1,193 64,489 SH   OTR   0 64,489 0
MPLX LP COM UNIT REP LTD 55336V100 35,769 1,021,677 SH   OTR   0 1,021,677 0
MYOKARDIA INC COM 62857M105 478 11,162 SH   OTR   0 11,162 0
NEKTAR THERAPEUTICS COM 640268108 1,347 56,131 SH   OTR   0 56,131 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 1,443 23,551 SH   OTR   0 23,551 0
NGL ENERGY PARTNERS LP COM UNIT REPST 62913M107 7,132 617,529 SH   OTR   0 617,529 0
NOVAVAX INC COM 670002104 351 308,286 SH   OTR   0 308,286 0
NUSTAR ENERGY LP UNIT COM 67058H102 10,555 260,030 SH   OTR   0 260,030 0
OMEROS CORP COM 682143102 1,019 47,112 SH   OTR   0 47,112 0
ONEOK INC NEW COM 682680103 16,643 300,355 SH   OTR   0 300,355 0
ONEOK INC NEW PUT 682680953 20 2,000 SH Put OTR   0 2,000 0
ONEOK INC NEW CALL 682680903 1 201 SH Call OTR   0 201 0
PARATEK PHARMACEUTICALS INC COM 699374302 370 14,726 SH   OTR   0 14,726 0
PHILLIPS 66 PARTNERS LP COM UNIT REP INT 718549207 14,955 284,541 SH   OTR   0 284,541 0
PLAINS ALL AMERN PIPELINE L UNIT LTD PARTN 726503105 15,284 721,306 SH   OTR   0 721,306 0
PLAINS ALL AMERN PIPELINE L CALL 726503905 2 450 SH Call OTR   0 450 0
PORTOLA PHARMACEUTICALS INC COM 737010108 483 8,940 SH   OTR   0 8,940 0
PROGENICS PHARMACEUTICALS IN COM 743187106 1,096 148,929 SH   OTR   0 148,929 0
PROSHARES TR PSHS ULTRA UTIL 74347R685 277 5,800 SH   OTR   0 5,800 0
PROTHENA CORP PLC SHS G72800108 392 6,048 SH   OTR   0 6,048 0
PTC THERAPEUTICS INC COM 69366J200 392 19,612 SH   OTR   0 19,612 0
PUMA BIOTECHNOLOGY INC COM 74587V107 497 4,147 SH   OTR   0 4,147 0
RADIUS HEALTH INC COM NEW 750469207 960 24,899 SH   OTR   0 24,899 0
REATA PHARMACEUTICALS INC CL A 75615P103 402 12,925 SH   OTR   0 12,925 0
REGENERON PHARMACEUTICALS COM 75886F107 971 2,171 SH   OTR   0 2,171 0
REGENXBIO INC COM 75901B107 569 17,271 SH   OTR   0 17,271 0
RETROPHIN INC COM 761299106 1,410 56,653 SH   OTR   0 56,653 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 321 126,385 SH   OTR   0 126,385 0
SAGE THERAPEUTICS INC COM 78667J108 264 4,234 SH   OTR   0 4,234 0
SANGAMO BIOSCIENCES INC COM 800677106 660 43,982 SH   OTR   0 43,982 0
SAREPTA THERAPEUTICS INC COM 803607100 1,417 31,233 SH   OTR   0 31,233 0
SEATTLE GENETICS INC COM 812578102 881 16,188 SH   OTR   0 16,188 0
SERES THERAPEUTICS INC COM 81750R102 518 32,276 SH   OTR   0 32,276 0
SHELL MIDSTREAM PARTNERS L P UNIT LTD INT 822634101 501 18,010 SH   OTR   0 18,010 0
SPARK THERAPEUTICS INC COM 84652J103 519 5,818 SH   OTR   0 5,818 0
SPDR S&P 500 ETF TR CALL 78462F903 111 1,800 SH Call OTR   0 1,800 0
SPECTRA ENERGY PARTNERS LP COM 84756N109 993 22,367 SH   OTR   0 22,367 0
SYNERGY PHARMACEUTICALS DEL COM NEW 871639308 716 247,030 SH   OTR   0 247,030 0
TALLGRASS ENERGY PARTNERS LP COM UNIT 874697105 9,775 204,111 SH   OTR   0 204,111 0
TARGA RES CORP COM 87612G101 4,287 90,638 SH   OTR   0 90,638 0
TC PIPELINES LP UT COM LTD PRT 87233Q108 6,463 123,526 SH   OTR   0 123,526 0
TESARO INC COM 881569107 916 7,097 SH   OTR   0 7,097 0
TETRAPHASE PHARMACEUTICALS I COM 88165N105 308 45,001 SH   OTR   0 45,001 0
TG THERAPEUTICS INC COM 88322Q108 349 29,453 SH   OTR   0 29,453 0
THERAVANCE BIOPHARMA INC COM G8807B106 947 27,646 SH   OTR   0 27,646 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 285 5,343 SH   OTR   0 5,343 0
UNITED STATES NATL GAS FUND CALL 912318901 82 41,012 SH Call OTR   0 41,012 0
UNITED STATES NATL GAS FUND PUT 912318951 4 744 SH Put OTR   0 744 0
UNITED STATES OIL FUND LP CALL 91232N908 175 87,212 SH Call OTR   0 87,212 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 932 7,952 SH   OTR   0 7,952 0
VANDA PHARMACEUTICALS INC COM 921659108 1,338 74,733 SH   OTR   0 74,733 0
VANECK VECTORS ETF TR GOLD MINERS ETF 92189F106 853 37,167 SH   OTR   0 37,167 0
VANGUARD INDEX FDS REIT ETF 922908553 641 7,711 SH   OTR   0 7,711 0
VANGUARD WORLD FDS ENERGY ETF 92204A306 1,717 18,349 SH   OTR   0 18,349 0
VANGUARD WORLD FDS UTILITIES ETF 92204A876 3,418 29,270 SH   OTR   0 29,270 0
VERSARTIS INC COM 92529L102 49 19,991 SH   OTR   0 19,991 0
VERTEX PHARMACEUTICALS INC COM 92532F100 1,262 8,300 SH   OTR   0 8,300 0
WELLTOWER INC 6.50% PFD PREPET 95040Q203 1,638 25,828 SH   OTR   0 25,828 0
WESTERN GAS EQUITY PARTNERS COMUNT LTD PT 95825R103 5,762 139,927 SH   OTR   0 139,927 0
WESTERN GAS PARTNERS LP COM UNIT LP IN 958254104 12,649 246,660 SH   OTR   0 246,660 0
WILLIAMS COS INC DEL COM 969457100 9,512 316,952 SH   OTR   0 316,952 0
WILLIAMS COS INC DEL PUT 969457950 4 800 SH Put OTR   0 800 0
WILLIAMS PARTNERS L P NEW COM UNIT LTD PAR 96949L105 65,031 1,671,737 SH   OTR   0 1,671,737 0
XENCOR INC COM 98401F105 364 15,881 SH   OTR   0 15,881 0
ZIOPHARM ONCOLOGY INC COM 98973P101 362 59,009 SH   OTR   0 59,009 0