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Debt - Sale of Future Royalty Interest (Details) - USD ($)
1 Months Ended 12 Months Ended
Apr. 13, 2021
Mar. 08, 2021
Dec. 22, 2020
Dec. 10, 2020
Nov. 13, 2020
Oct. 08, 2020
Aug. 10, 2020
Nov. 30, 2020
Mar. 31, 2020
Dec. 31, 2021
Dec. 31, 2020
Jan. 13, 2021
Nov. 01, 2020
Oct. 31, 2020
Jul. 10, 2020
Oct. 31, 2019
Iliad                                
Debt Instrument [Line Items]                                
Royalty Expense $ 3,000,000.0                              
Issuance of common stock (In shares) 588,235                              
Tempesta Note                                
Debt Instrument [Line Items]                                
Principal amount                               $ 550,000
Carrying value of notes                   $ 350,000 $ 450,000          
Streeterville Note                                
Debt Instrument [Line Items]                                
Principal amount                       $ 6,200,000        
Aggregate purchase price                       $ 6,000,000.0        
March 2020 Purchase Agreement                                
Debt Instrument [Line Items]                                
Royalty interest                 $ 500,000              
Notes payable                 150,000              
Principal amount of debt                 500,000              
Payments for Royalties                 283,000              
Royalty payments due       $ 0                        
Aggregate purchase price                 $ 350,000              
Percentage of net sales                   10.00%            
Percentage of worldwide revenues                   10.00%            
Royalty discount rate                 105.00%              
Increase in Royalty Repayment, Percent                             10.00%  
Shares issued to Iliad in exchange of Royalty Interest (in shares)               1,314,974                
Royalty Instrument, Debt Instrument Carrying Value                     0          
March 2020 Purchase Agreement | Beginning on September 4, 2020                                
Debt Instrument [Line Items]                                
Minimum monthly royalty repayment amount                   $ 25,000            
March 2020 Purchase Agreement | Beginning on March 2021                                
Debt Instrument [Line Items]                                
Minimum monthly royalty repayment amount                   44,000            
October 2020 Purchase Agreement                                
Debt Instrument [Line Items]                                
Royalty interest           $ 12,000,000.0                    
Payments for Royalties           12,000,000.0                    
Aggregate purchase price           $ 6,000,000.0                    
Percentage of net sales           10.00%                    
Percentage of worldwide revenues           10.00%                    
Minimum Volume Weighted Average Price                         $ 0.9105 $ 0.9105    
Increase In Royalty Repayment Amount           $ 6,000,000.0                    
Additional Royalty Financings Committed         $ 6,000,000.0                      
Carrying value of notes                   6,300,000 6,600,000          
Interest expense                   4,200,000 543,000          
Royalty discount             $ 6,000,000.0     $ 77.09            
Royalty discount rate         45.42%   34.51%     74.59%            
October 2020 Purchase Agreement | Beginning On April 2021                                
Debt Instrument [Line Items]                                
Minimum monthly royalty repayment amount             $ 250,000                  
October 2020 Purchase Agreement | Beginning On October 2021                                
Debt Instrument [Line Items]                                
Minimum monthly royalty repayment amount             $ 400,000                  
October 2020 Purchase Agreement | Beginning On April 2022                                
Debt Instrument [Line Items]                                
Minimum monthly royalty repayment amount           600,000                    
October 2020 Purchase Agreement | Beginning On October 2022                                
Debt Instrument [Line Items]                                
Minimum monthly royalty repayment amount           $ 750,000                    
December 2020 Purchase Agreement                                
Debt Instrument [Line Items]                                
Principal amount                     1,000,000.0          
Royalty interest     $ 12,000,000.0                          
Aggregate purchase price     $ 6,000,000.0                          
Percentage of net sales     10.00%                          
Percentage of worldwide revenues     10.00%                          
Minimum monthly royalty repayment amount     $ 750,000                          
Carrying value of notes                   $ 7,600,000 6,000,000.0          
Interest expense                   $ 2,900,000 $ 14,000          
Royalty discount     $ 6,000,000.0                          
Royalty discount rate     23.70%             23.28%            
March 2021 Purchase Agreement [Member]                                
Debt Instrument [Line Items]                                
Aggregate purchase price   $ 5,000,000.0                            
Percentage of net sales   10.00%                            
Percentage of worldwide revenues   10.00%                            
Carrying value of notes                   $ 5,800,000            
Interest expense                   $ 1,200,000            
Percentage of royalties collected from licenses   50.00%                            
Threshold price   $ 10,000,000.0                            
March 2021 Purchase Agreement [Member] | Beginning on March 2021                                
Debt Instrument [Line Items]                                
Royalty interest   10,000,000.0                            
Royalty discount   $ 5,000,000.0                            
Royalty discount rate   19.36%               19.14%            
March 2021 Purchase Agreement [Member] | Beginning On April 2021                                
Debt Instrument [Line Items]                                
Minimum monthly royalty repayment amount   $ 250,000                            
Increase in Royalty Repayment, Percent   5.00%                            
March 2021 Purchase Agreement [Member] | Beginning On October 2021                                
Debt Instrument [Line Items]                                
Minimum monthly royalty repayment amount   $ 400,000                            
March 2021 Purchase Agreement [Member] | Beginning On April 2022                                
Debt Instrument [Line Items]                                
Increase in Royalty Repayment, Percent   10.00%                            
Royalty Instrument, Debt Instrument Carrying Value   $ 600,000                            
March 2021 Purchase Agreement [Member] | Beginning On October 2022                                
Debt Instrument [Line Items]                                
Minimum monthly royalty repayment amount   $ 750,000