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Collaboration Agreements and Other Contractual Arrangements (Details) - USD ($)
$ in Millions
3 Months Ended 9 Months Ended
Sep. 30, 2017
Oct. 01, 2016
Sep. 30, 2017
Oct. 01, 2016
Research and development $ 38.4 $ 50.2 $ 120.8 $ 142.5