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Collaboration agreements and other contractual arrangements (Details) - USD ($)
$ in Millions
 1 Months Ended 9 Months Ended
Jun. 30, 2016
May 31, 2015
Oct. 01, 2016
Minimum [Member] | May 2015 agreement [Member]      
Potential Contingent Milestone Payments   $ 78.0  
Minimum [Member] | June 2016 agreement [Member]      
Potential Contingent Milestone Payments $ 42.0    
Maximum [Member] | May 2015 agreement [Member]      
Potential Contingent Milestone Payments   $ 105.0  
Maximum [Member] | June 2016 agreement [Member]      
Potential Contingent Milestone Payments     $ 57.0