The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIVAX SA SPONSORED ADS 00370M103   30,459,000 2,130,000 SH   DFND 1 2,130,000 0 0
AEROVATE THERAPEUTICS INC COM 008064107   31,633,868 1,069,796 SH   DFND 1 1,069,796 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100   107,028,000 2,700,000 SH   DFND 1 2,700,000 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105   35,034,181 3,142,079 SH   DFND 1 3,142,079 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   23,512,000 400,000 SH   DFND 1 400,000 0 0
ARCELLX INC COMMON STOCK 03940C100   123,799,000 1,780,000 SH   DFND 1 1,780,000 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108   21,058,750 2,125,000 SH   DFND 1 2,125,000 0 0
ARRIVENT BIOPHARMA INC COM 04272N102   9,197,900 515,000 SH   DFND 1 515,000 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   18,297,500 1,300,000 SH   DFND 1 1,300,000 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   42,214,335 6,616,667 SH   DFND 1 6,616,667 0 0
BEAM THERAPEUTICS INC COM 07373V105   9,912,000 300,000 SH Put DFND 1 300,000 0 0
BIOATLA INC COM 09077B104   4,027,793 1,170,870 SH   DFND 1 1,170,870 0 0
BIOHAVEN LTD COM G1110E107   33,741,706 616,963 SH   DFND 1 616,963 0 0
BIOMEA FUSION INC COM 09077A106   53,384,536 3,570,872 SH   DFND 1 3,570,872 0 0
BRIDGEBIO PHARMA INC COM 10806X102   99,037,657 3,203,029 SH   DFND 1 3,203,029 0 0
CABALETTA BIO INC COM 12674W109   18,766,000 1,100,000 SH   DFND 1 1,100,000 0 0
CARGO THERAPEUTICS INC COM 14179K101   26,394,806 1,182,563 SH   DFND 1 1,182,563 0 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100   6,346,080 561,600 SH   DFND 1 561,600 0 0
CG ONCOLOGY INC COM 156944100   35,120,000 800,000 SH   DFND 1 800,000 0 0
COMPASS THERAPEUTICS INC COM 20454B104   11,009,394 5,560,300 SH   DFND 1 5,560,300 0 0
CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301   79,461,000 2,025,000 SH   DFND 1 2,025,000 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   53,831,500 1,150,000 SH   DFND 1 1,150,000 0 0
DISC MEDICINE INC COM 254604101   7,782,500 125,000 SH   DFND 1 125,000 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   54,839,180 3,006,534 SH   DFND 1 3,006,534 0 0
ENGENE HOLDINGS INC COM 29286M105   16,950,000 1,000,000 SH   DFND 1 1,000,000 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209   142,483,167 6,893,235 SH   DFND 1 6,893,235 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106   6,321,838 593,043 SH   DFND 1 593,043 0 0
HELIX ACQUISITION CORP II CL A ORD SHS G4444H101   30,253,600 2,909,000 SH   DFND 1 2,909,000 0 0
IDEAYA BIOSCIENCES INC COM 45166A102   19,746,000 450,000 SH   DFND 1 450,000 0 0
IMMUNEERING CORP CLASS A COM 45254E107   9,523,339 3,295,273 SH   DFND 1 3,295,273 0 0
INSMED INC COM PAR $.01 457669307   15,599,750 575,000 SH   DFND 1 575,000 0 0
JANUX THERAPEUTICS INC COM 47103J105   28,237,500 750,000 SH   DFND 1 750,000 0 0
KORRO BIO INC COM 500946108   47,625,300 529,170 SH   DFND 1 529,170 0 0
KYVERNA THERAPEUTICS INC COM 501976104   10,929,600 440,000 SH   DFND 1 440,000 0 0
LANTHEUS HLDGS INC COM 516544103   4,668,000 75,000 SH   DFND 1 75,000 0 0
LONGBOARD PHARMACEUTICALS IN COM 54300N103   72,427,846 3,353,141 SH   DFND 1 3,353,141 0 0
MARINUS PHARMACEUTICALS INC COM NEW 56854Q200   29,380,000 3,250,000 SH   DFND 1 3,250,000 0 0
MERSANA THERAPEUTICS INC COM 59045L106   11,648,000 2,600,000 SH   DFND 1 2,600,000 0 0
MERUS N V COM N5749R100   32,196,450 715,000 SH   DFND 1 715,000 0 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104   426,661,205 8,494,151 SH   DFND 1 8,494,151 0 0
NEUROGENE INC COM 64135M105   27,420,543 538,714 SH   DFND 1 538,714 0 0
NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES N62509109   35,475,000 1,500,000 SH   DFND 1 1,500,000 0 0
NKARTA INC COM 65487U108   14,593,500 1,350,000 SH   DFND 1 1,350,000 0 0
PHARVARIS N V COM N69605108   39,551,841 1,711,460 SH   DFND 1 1,711,460 0 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207   79,936,200 1,310,000 SH   DFND 1 1,310,000 0 0
RAPT THERAPEUTICS INC COM 75382E109   4,460,815 496,750 SH   DFND 1 496,750 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   23,831,500 550,000 SH   DFND 1 550,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   8,082,000 300,000 SH   DFND 1 300,000 0 0
SILENCE THERAPEUTICS PLC ADS 82686Q101   13,500,000 625,000 SH   DFND 1 625,000 0 0
SPYRE THERAPEUTICS INC COM NEW 00773J202   9,482,500 250,000 SH   DFND 1 250,000 0 0
STOKE THERAPEUTICS INC COM 86150R107   5,766,701 427,163 SH   DFND 1 427,163 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103   77,756,358 2,139,102 SH   DFND 1 2,139,102 0 0
TOURMALINE BIO INC COM 89157D105   28,625,000 1,250,000 SH   DFND 1 1,250,000 0 0
VAXCYTE INC COM 92243G108   46,792,350 685,000 SH   DFND 1 685,000 0 0
VENTYX BIOSCIENCES INC COM 92332V107   14,905,000 2,710,000 SH   DFND 1 2,710,000 0 0
VERVE THERAPEUTICS INC COM 92539P101   4,648,000 350,000 SH   DFND 1 350,000 0 0
VYNE THERAPEUTICS INC COM 92941V308   4,280,612 1,394,336 SH   DFND 1 1,394,336 0 0