The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | 1,130 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| ACCELERON PHARMA INC | COM | 00434H108 | 6,794 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| ACELRX PHARMACEUTICALS INC | COM | 00444T100 | 7,175 | 700,000 | SH | DFND | 1 | 700,000 | 0 | 0 | |
| AGENUS INC | COM NEW | 00847G705 | 2,898 | 900,000 | SH | DFND | 1 | 900,000 | 0 | 0 | |
| AGILE THERAPEUTICS INC | COM | 00847L100 | 1,308 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| AKEBIA THERAPEUTICS INC | COM | 00972D105 | 11,116 | 400,000 | SH | DFND | 1 | 400,000 | 0 | 0 | |
| ALDER BIOPHARMACEUTICALS INC | COM | 014339105 | 3,011 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| ALKERMES PLC | SHS | G01767105 | 5,033 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 3,159 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| APPLIED GENETIC TECHNOLOGIES | COM | 03820J100 | 5,050 | 218,600 | SH | DFND | 1 | 218,600 | 0 | 0 | |
| AQUINOX PHARMACEUTICALS INC | COM | 03842B101 | 2,829 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 4,560 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| ARROWHEAD RESH CORP | COM NEW | 042797209 | 12,879 | 900,000 | SH | DFND | 1 | 900,000 | 0 | 0 | |
| AUSPEX PHARMACEUTICALS INC | COM | 05211J102 | 2,227 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| BIOCRYST PHARMACEUTICALS | COM | 09058V103 | 14,892 | 1,168,000 | SH | DFND | 1 | 1,168,000 | 0 | 0 | |
| CELGENE CORP | COM | 151020104 | 17,176 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| CELSUS THERAPEUTICS PLC | SPONSORED ADR NE | 15119A202 | 639 | 103,000 | SH | DFND | 1 | 103,000 | 0 | 0 | |
| CERULEAN PHARMA INC | COM | 15708Q105 | 2,610 | 450,000 | SH | DFND | 1 | 450,000 | 0 | 0 | |
| CHIMERIX INC | COM | 16934W106 | 6,582 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| CHINA BIOLOGIC PRODS INC | COM | 16938C106 | 4,447 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| CLOVIS ONCOLOGY INC | COM | 189464100 | 2,899 | 70,000 | SH | DFND | 1 | 70,000 | 0 | 0 | |
| CURIS INC | COM | 231269101 | 1,116 | 600,000 | SH | DFND | 1 | 600,000 | 0 | 0 | |
| DEXCOM INC | COM | 252131107 | 7,932 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| DYAX CORP | COM | 26746E103 | 17,280 | 1,800,000 | SH | DFND | 1 | 1,800,000 | 0 | 0 | |
| EAGLE PHARMACEUTICALS INC | COM | 269796108 | 5,732 | 400,000 | SH | DFND | 1 | 400,000 | 0 | 0 | |
| GALECTIN THERAPEUTICS INC | COM NEW | 363225202 | 11,048 | 800,000 | SH | DFND | 1 | 800,000 | 0 | 0 | |
| GENVEC INC | COM NEW | 37246C307 | 3,416 | 1,329,300 | SH | DFND | 1 | 1,329,300 | 0 | 0 | |
| GLYCOMIMETICS INC | COM | 38000Q102 | 3,981 | 472,300 | SH | DFND | 1 | 472,300 | 0 | 0 | |
| HERON THERAPEUTICS INC | COM | 427746102 | 8,624 | 700,000 | SH | DFND | 1 | 700,000 | 0 | 0 | |
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 14,701 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| KARYOPHARM THERAPEUTICS INC | COM | 48576U106 | 17,922 | 385,000 | SH | DFND | 1 | 385,000 | 0 | 0 | |
| KINDRED BIOSCIENCES INC | COM | 494577109 | 1,864 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| MALLINCKRODT PUB LTD CO | SHS | G5785G107 | 7,202 | 90,000 | SH | DFND | 1 | 90,000 | 0 | 0 | |
| MERCK & CO INC NEW | COM | 58933Y105 | 5,785 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| NANOSTRING TECHNOLOGIES INC | COM | 63009R109 | 4,485 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 4,451 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| NOVAVAX INC | COM | 670002104 | 6,930 | 1,500,000 | SH | DFND | 1 | 1,500,000 | 0 | 0 | |
| OMEROS CORP | COM | 682143102 | 19,540 | 1,123,000 | SH | DFND | 1 | 1,123,000 | 0 | 0 | |
| PUMA BIOTECHNOLOGY INC | CALL | 74587V907 | 4,500 | 5,000 | SH | DFND | 1 | 5,000 | 0 | 0 | |
| PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 5,836 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| PTC THERAPEUTICS INC | COM | 69366J200 | 3,921 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| PUMA BIOTECHNOLOGY INC | COM | 74587V107 | 13,695 | 207,500 | SH | DFND | 1 | 207,500 | 0 | 0 | |
| QUESTCOR PHARMACEUTICALS INC | COM | 74835Y101 | 18,498 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| QUOTIENT LTD | COM | G73268107 | 4,180 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| RECEPTOS INC | COM | 756207106 | 20,397 | 478,800 | SH | DFND | 1 | 478,800 | 0 | 0 | |
| RECRO PHARMA INC | COM | 75629F109 | 4,005 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| REGULUS THERAPEUTICS INC | COM | 75915K101 | 1,608 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| ROCKWELL MED INC | COM | 774374102 | 4,796 | 400,000 | SH | DFND | 1 | 400,000 | 0 | 0 | |
| SANGAMO BIOSCIENCES INC | COM | 800677106 | 7,635 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| SCYNEXIS INC | COM | 811292101 | 802 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| SORRENTO THERAPEUTICS INC | COM NEW | 83587F202 | 6,750 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| TESARO INC | COM | 881569107 | 9,333 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| ULTRAGENYX PHARMACEUTICAL INC | COM | 90400D108 | 5,387 | 120,000 | SH | DFND | 1 | 120,000 | 0 | 0 | |
| VERSARTIS INC | COM | 92529L102 | 5,608 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |