Exhibit 16.1

Tel: 301-354-2500
Fax: 301-354-2501
www.bdo.com 12505 Park Potomac Ave, Suite 700
Potomac, MD 20854

January 2, 2024

Securities and Exchange Commission 100 F Street N.E.

Washington, D.C. 20549

We have been furnished with a copy of the response to Item 4.01 of Form 8-K for the event that occurred on December 27, 2023, to be filed by our former client, Hepion Pharmaceuticals, Inc. We agree with the statements made in response to that Item insofar as they relate to our Firm.

Very truly yours,

/s/ BDO USA