Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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The amount of expense recognized in the current period that reflects the allocation of the cost of tangible assets over the assets' useful lives. Includes production and non-production related depreciation.

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The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale.

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Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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Amount after accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business to produce goods and services and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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Property and Equipment (Details) - USD ($) $ in Thousands	1 Months Ended	12 Months Ended
Property and Equipment (Details) - USD ($) $ in Thousands	Jan. 31, 2022	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Property and Equipment
Property and equipment, gross		$ 44,711	$ 52,149
Less: accumulated depreciation		(32,836)	(38,492)
Property and equipment, net		11,875	13,657
Depreciation expense		2,600	3,500	$ 3,300
Proceeds from the sale of property and equipment		1,866	6	$ 64
Computer equipment
Property and Equipment
Property and equipment, gross		1,921	2,341
Software
Property and Equipment
Property and equipment, gross		1,088	2,063
Furniture and fixtures
Property and Equipment
Property and equipment, gross		1,674	3,605
Laboratory equipment
Property and Equipment
Property and equipment, gross		15,445	20,087
Leasehold improvements
Property and Equipment
Property and equipment, gross		$ 24,583	$ 24,053
Property and equipment
Property and Equipment
Proceeds from the sale of property and equipment	$ 1,900