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Revenue - Janssen Biotech Agreement (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Feb. 28, 2018
Sep. 30, 2021
Sep. 30, 2020
Sep. 30, 2021
Sep. 30, 2020
Collaborative Arrangements and Co-Promote Agreement          
Revenues   $ 13,194 $ 18,257 $ 40,365 $ 53,127
Percentage of profit share 33.00%     35.00%  
Research and development   43,739 67,371 $ 162,431 195,788
Janssen          
Collaborative Arrangements and Co-Promote Agreement          
Upfront payment receivable $ 100,000     100,000  
Percentage of profit share 67.00%        
Revenue from collaborative arrangements   2,788 7,252 8,621 19,353
Deferred revenue   2,800   2,800  
Research and development   $ 4,700 $ 9,800 $ 18,300 $ 29,000
Janssen | Collaborative Arrangement          
Collaborative Arrangements and Co-Promote Agreement          
Upfront payment receivable $ 100,000        
Janssen | Collaborative Arrangement | Izencitinib          
Collaborative Arrangements and Co-Promote Agreement          
Collaborative arrangement, opt in fee $ 200,000