The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 6,973 250,000 SH   SOLE   250,000 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 2,441 90,000 SH   SOLE   90,000 0 0
ACORDA THERAPEUTICS INC COM 00484M106 591 30,000 SH Put SOLE   30,000 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 2,102 40,000 SH Put SOLE   40,000 0 0
ALIMERA SCIENCES INC COM 016259103 1,354 974,318 SH   SOLE   974,318 0 0
ANAPTYSBIO INC COM 032724106 3,965 165,690 SH   SOLE   165,690 0 0
ARGENX SE SPONSORED ADR 04016X101 3,242 152,837 SH   SOLE   152,837 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 25,664 924,483 SH   SOLE   924,483 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 21,271 1,030,072 SH   SOLE   1,030,072 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 3,820 185,000 SH Call SOLE   0 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 938 168,685 SH   SOLE   168,685 0 0
CAS MED SYS INC COM PAR 124769209 5,522 4,760,151 SH   SOLE   4,760,151 0 0
CHEMBIO DIAGNOSTICS INC COM NEW 163572209 8,218 1,358,351 SH   SOLE   1,358,351 0 0
CLOVIS ONCOLOGY INC COM 189464100 1,873 20,000 SH   SOLE   20,000 0 0
CYTOKINETICS INC COM NEW 23282W605 484 40,000 SH Put SOLE   40,000 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 3,848 107,765 SH   SOLE   107,765 0 0
EDGE THERAPEUTICS INC COM 279870109 15,437 1,504,612 SH   SOLE   1,504,612 0 0
ESSA PHARMA INC COM 29668H104 242 442,000 SH   SOLE   442,000 0 0
EVOLENT HEALTH INC CL A 30050B101 7,113 280,600 SH   SOLE   280,600 0 0
EXELIXIS INC COM 30161Q104 1,724 70,000 SH Put SOLE   70,000 0 0
GLAUKOS CORP COM 377322102 999 24,100 SH Put SOLE   24,100 0 0
GOGO INC COM 38046C109 577 50,000 SH Put SOLE   50,000 0 0
IMMUNOGEN INC COM 45253H101 356 50,000 SH Call SOLE   0 0 0
IMMUNOMEDICS INC COM 452907108 14,128 1,600,000 SH   SOLE   1,600,000 0 0
INSMED INC COM PAR $.01 457669307 858 50,000 SH Put SOLE   50,000 0 0
INTEC PHARMA LTD JERUSALEM SHS M53644106 2,280 400,000 SH   SOLE   400,000 0 0
INVITAE CORP COM 46185L103 959 100,292 SH   SOLE   100,292 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 25,101 3,415,044 SH   SOLE   3,415,044 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 2,381 324,000 SH Call SOLE   0 0 0
IRIDEX CORP COM 462684101 17,184 1,737,540 SH   SOLE   1,737,540 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 51,436 365,000 SH Put SOLE   365,000 0 0
JOHNSON & JOHNSON COM 478160104 5,292 40,000 SH Put SOLE   40,000 0 0
JUNO THERAPEUTICS INC COM 48205A109 2,391 80,000 SH Put SOLE   80,000 0 0
KITE PHARMA INC COM 49803L109 7,775 75,000 SH   SOLE   75,000 0 0
LANNET INC COM 516012101 1,828 89,600 SH Put SOLE   89,600 0 0
MANNKIND CORP COM NEW 56400P706 46 32,300 SH Put SOLE   32,300 0 0
MYRIAD GENETICS INC COM 62855J104 501 19,400 SH Put SOLE   19,400 0 0
NABRIVA THERAPEUTICS PLC SHS G63637105 9,911 945,737 SH   SOLE   945,737 0 0
NEURODERM LTD ORD SHS M74231107 2,179 72,866 SH   SOLE   72,866 0 0
NEURODERM LTD ORD SHS M74231107 299 10,000 SH Put SOLE   10,000 0 0
OMEROS CORP COM 682143102 796 40,000 SH Put SOLE   40,000 0 0
ONCOBIOLOGICS INC COM 68235M105 29 29,082 SH   SOLE   29,082 0 0
ONCOBIOLOGICS INC *W EXP 02/18/201 68235M113 17 96,833 SH   SOLE   96,833 0 0
ONCOBIOLOGICS INC *W EXP 05/18/201 68235M121 9 96,833 SH   SOLE   96,833 0 0
QUOTIENT LTD SHS G73268107 4,057 551,196 SH   SOLE   551,196 0 0
RA PHARMACEUTICALS INC COM 74933V108 7,000 373,507 SH   SOLE   373,507 0 0
RECRO PHARMA INC COM 75629F109 1,410 200,500 SH   SOLE   200,500 0 0
SANGAMO THERAPEUTICS INC COM 800677106 264 30,000 SH Put SOLE   30,000 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 29,506 382,300 SH Put SOLE   382,300 0 0
SPECTRANETICS CORP COM 84760C107 1,536 40,000 SH Put SOLE   40,000 0 0
TESARO INC COM 881569107 3,315 23,700 SH   SOLE   23,700 0 0
VERACYTE INC COM 92337F107 25,658 3,080,145 SH   SOLE   3,080,145 0 0
VERACYTE INC COM 92337F107 1,333 160,000 SH Call SOLE   0 0 0
VERSARTIS INC COM 92529L102 857 49,100 SH Put SOLE   49,100 0 0
VIEWRAY INC COM 92672L107 4,441 686,387 SH   SOLE   686,387 0 0
VIVEVE MED INC COM NEW 92852W204 5,098 710,000 SH   SOLE   710,000 0 0
WEBMD HEALTH CORP COM 94770V102 1,935 33,000 SH   SOLE   33,000 0 0
ZIOPHARM ONCOLOGY INC COM 98973P101 933 150,000 SH Put SOLE   150,000 0 0
ZOGENIX INC COM NEW 98978L204 4,375 301,700 SH   SOLE   301,700 0 0
ZOGENIX INC COM NEW 98978L204 1,450 100,000 SH Put SOLE   100,000 0 0