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Stock-based Compensation (Tables)
 12 Months Ended
Dec. 31, 2022
Share-Based Payment Arrangement [Abstract]  
Schedule of Recognized Stock-Based Compensation

The Company recognized stock-based compensation expense (options and restricted share grants) in the following expense categories of its consolidated statements of operations as follows:

Schedule of Recognized Stock-Based Compensation 

   Year Ended December 31, 
   2022   2021 
Research and Development  $2,400   $1,870 
General and Administrative   2,828    2,422 
Total  $5,228   $4,292 
Schedule of Equity Compensation Plan by Arrangements

The following table contains information about the Company’s stock plan at December 31, 2022:

Schedule of Equity Compensation Plan by Arrangements 

  Awards Reserved for Issuance   Awards Issued & Exercised   Awards Available for Grant 
2013 Equity Compensation Plan (in thousands)   45,603*   39,420**   6,183 

 

* Increased by 8,651 thousand on January 1, 2022, representing 4% of the total number of shares of common stock outstanding on December 31, 2021.
** Includes both stock grants and option grants
Schedule of Stock Option Activity

The following table summarizes the Company’ stock option activity and related information for the period from January 1, 2021 to December 31, 2022 (options in thousands):

Schedule of Stock Option Activity 

   Number of Options   Weighted Average Exercise Price   Weighted Average Contractual Term in Years 
Outstanding at December 31, 2020   22,551   $1.26    6.9 
Granted   10,976    1.11      
Exercised   (1,077)   0.60      
Forfeited   (2,824)   1.08      
Expired   (1,442)   1.98      
Outstanding at December 31, 2021   28,184   $1.21    7.2 
                
Granted   8,509    0.56      
Exercised   (195)   0.51      
Forfeited   (175)   0.96      
Expired   (1,584)   1.06      
Outstanding at December 31, 2022   34,739   $1.07    7.1 
Summary of Outstanding Options

The following table summarizes outstanding options at December 31, 2022, by their exercise price (options in thousands):

Range of Exercise Prices  Number Outstanding   Weighted Average Exercise Price Per Share 
$0.41 - $0.69   8,390   $0.52 
$0.73 - $0.92   9,828   $0.86 
$0.93 - $1.28   8,284   $1.08 
$1.36 - $3.32   8,237   $1.88 
    34,739   $1.07 
Schedule of Stock Option Awards and Restricted Stock Awards

 

   For the Year Ended December 31, 
   2022   2021 
Volatility   92.1% -98.7 %   98.4% - 101.6 %
Risk-free interest rate   1.57% - 4.32%   0.47% - 1.28 %
Dividend yield   0.0%   0.0%
Expected life   6.0 years    6.0 years