Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Operating expenses:
Research and development	$ 9,137	$ 5,568
General and administrative	2,621	2,238
Total operating expenses	11,758	7,806
Loss from operations	(11,758)	(7,806)
Other income (expense):
Interest income	682	108
Interest expense	(358)	(159)
Foreign exchange gain (loss)	130	(284)
Gain on termination of collaboration agreement (note 9c)		4,398
Loss before income taxes	(11,304)	(3,743)
Income tax expense (note 10)	(37)	(12)
Net loss and comprehensive loss	(11,341)	(3,755)
Net loss attributable to preferred shareholders	(430)	(33)
Net loss attributable to common shareholders	$ (10,911)	$ (3,722)
Net loss per common share (note 4):
Basic	$ (0.42)	$ (0.21)
Diluted	$ (0.42)	$ (0.21)
Weighted-average common shares outstanding (note 4):
Basic	25,753,836	17,804,421
Diluted	25,753,836	17,804,421