Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Revenue:
Collaboration revenue (note 11)	$ 309	$ 1,767	$ 15,573
Royalties	2	36	4
Revenues	311	1,803	15,577
Operating expenses:
Research and development	25,573	19,828	15,152
General and administrative	7,313	6,792	9,786
Total operating expenses	32,886	26,620	24,938
Loss from operations	(32,575)	(24,817)	(9,361)
Other income (expense):
Interest income	477	504	542
Foreign exchange gain (loss)	1,394	1,316	(6,933)
Net loss and comprehensive loss	$ (30,704)	$ (22,997)	$ (15,752)
Net loss per common share (note 5):
Basic	$ (1.71)	$ (1.48)	$ (1.10)
Diluted	$ (1.72)	$ (1.48)	$ (1.10)
Weighted-average common shares outstanding (note 5):
Basic	17,985,061	15,493,474	14,281,837
Diluted	18,001,759	15,493,474	14,281,837