Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
Operating activities:
Net loss	$ (105,855)	$ (89,188)
Items not involving cash:
Depreciation	1,258	956
Deferred income tax expense	70	64
Stock-based compensation	24,116	14,447
Unrealized foreign exchange (gain) loss	118	(452)
Unrealized fair value gain on trading securities		(2,914)
Changes in operating assets and liabilities:
Accounts receivable	16	269
Prepaid expenses and other current assets	285	4,199
Accounts payable and accrued expenses	4,135	4,987
Net cash used in operating activities	(75,857)	(67,632)
Investing activities:
Purchases of property, plant and equipment	(1,702)	(4,339)
Purchases of marketable securities	(301,826)	(270,554)
Proceeds from marketable securities	368,045	349,417
Net cash provided by investing activities	64,517	74,524
Effect of exchange rate changes on cash and cash equivalents	(569)	418
Increase (decrease) in cash and cash equivalents	(11,909)	7,310
Cash and cash equivalents, beginning of period	148,643	57,242
Cash and cash equivalents, end of period	136,734	64,552
Supplemental disclosure:
Cash paid for operating lease	819	709
Supplemental disclosures of non-cash transactions:
Fair value of stock options exercised on a cashless basis	$ 4,084	3,114
Fair value of pre-funded warrants exercised		14,758
Increase in operating lease liability and accounts receivable related to lease incentives claimed in the period		$ 1,380