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Related Party Transactions - Additional Information (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 2 Months Ended 12 Months Ended
Jan. 12, 2023
Jun. 01, 2021
Nov. 30, 2022
Oct. 31, 2021
Jun. 30, 2021
Feb. 28, 2021
Feb. 16, 2023
Dec. 31, 2022
Dec. 31, 2021
Aug. 31, 2021
Jul. 31, 2021
Dec. 31, 2020
Related Party Transaction [Line Items]                        
Common stock, shares outstanding               8,928,498 7,274,889      
Interest expense               $ 10,990 $ 12,636      
Issuance of common stock                 173,477      
Warrants to purchase number of common stock, shares                   77,280 20,000  
Warrants exercise price                 $ 25.00   $ 0.025  
7.25% Convertible Senior Notes due 2025                        
Related Party Transaction [Line Items]                        
Interest expense               $ 9,600 $ 11,700      
Debt instrument, annual interest rate                       7.25%
Securities Purchase Agreement                        
Related Party Transaction [Line Items]                        
Common stock outstanding, percentage     5.00%                  
Stock price     $ 7.50                  
Proceeds from waiver of cash interest payment obligation     $ 3,800                  
Subsequent Event | Securities Purchase Agreement                        
Related Party Transaction [Line Items]                        
Issuance of common stock             2,853,109          
Warrants to purchase number of common stock, shares 90,000                      
Warrants exercise price $ 8.22                      
Date from which warrants are exercisable May 09, 2023                      
Warrants maturity date May 09, 2028                      
Private Placement | Securities Purchase Agreement                        
Related Party Transaction [Line Items]                        
Issuance of common stock         647,773 174,825            
Stock price         $ 61.75 $ 143.00            
Warrants to purchase number of common stock, shares         647,773 174,825     243,886      
Warrants exercise price         $ 71.00 $ 171.50     $ 71.00      
Common Stock                        
Related Party Transaction [Line Items]                        
Issuance of common stock       340,554       1,117,155 3,006,481      
Common Stock | Securities Purchase Agreement                        
Related Party Transaction [Line Items]                        
Issuance of common stock     800,000 533,333                
Warrants to purchase number of common stock, shares     800,000                  
Common Stock | Private Placement | Securities Purchase Agreement                        
Related Party Transaction [Line Items]                        
Issuance of common stock         627,773 174,825            
Athyrium                        
Related Party Transaction [Line Items]                        
Common stock, shares outstanding               1,694,484 1,157,405      
Common stock outstanding, percentage               19.00% 15.60%      
Aggregate principal amount of convertible notes               $ 103,500 $ 103,500      
Accrued interest expense               $ 600 $ 600      
Interest expense   $ 3,600                    
Issuance of common stock               50,724        
Athyrium | Securities Purchase Agreement                        
Related Party Transaction [Line Items]                        
Stock price     $ 7.50                  
Warrants exercise price     $ 8.22                  
Proceeds from waiver of cash interest payment obligation     $ 3,800                  
Athyrium | Securities Purchase Agreement | 7.25% Convertible Senior Notes due 2025                        
Related Party Transaction [Line Items]                        
Interest expense     $ 3,800                  
Debt instrument, annual interest rate     7.25%                  
Athyrium | Common Stock                        
Related Party Transaction [Line Items]                        
Class of Warrant or Right, Outstanding               824,136        
Warrants to purchase number of common stock, shares                 323,883      
Athyrium | Common Stock | Securities Purchase Agreement                        
Related Party Transaction [Line Items]                        
Issuance of common stock     500,250                  
Warrants to purchase number of common stock, shares     500,250                  
Athyrium | Common Stock | Amend outstanding warrants                        
Related Party Transaction [Line Items]                        
Warrants to purchase number of common stock, shares     323,886                  
Warrants exercise price     $ 71.00                  
Athyrium | Common Stock | Private Placement                        
Related Party Transaction [Line Items]                        
Issuance of common stock         323,886              
Warrants exercise price               $ 8.22 $ 71.00      
Athyrium | Warrant [Member]                        
Related Party Transaction [Line Items]                        
Class of Warrant or Right, Outstanding                 16,006      
Athyrium | Warrant [Member] | Private Placement                        
Related Party Transaction [Line Items]                        
Shares issued, price per share         $ 61.75              
Common stock, shares outstanding         323,886              
Warrants exercise price                 $ 347.50