The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 7,382 192,200 SH   SOLE 192,200 0 0
ABBOTT LABS COM 002824100 157 4,100 SH   DFND 1 0 4,100 0
ADVANCED ACCELERATOR APPLIC SPONSORED ADS 00790T100 8 300 SH   DFND 1 0 300 0
ADVANCED ACCELERATOR APPLIC SPONSORED ADS 00790T100 377 14,100 SH   SOLE 14,100 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 148 3,900 SH   DFND 1 0 3,900 0
AERIE PHARMACEUTICALS INC COM 00771V108 7,002 185,000 SH   SOLE 185,000 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 54 2,600 SH   DFND 1 0 2,600 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 2,537 121,970 SH   SOLE 121,970 0 0
ALLERGAN PLC SHS G0177J108 693 3,300 SH   DFND 1 0 3,300 0
ALLERGAN PLC SHS G0177J108 32,636 155,400 SH   SOLE 155,400 0 0
ANTHEM INC COM 036752103 647 4,500 SH   DFND 1 0 4,500 0
ANTHEM INC COM 036752103 30,335 211,000 SH   SOLE 211,000 0 0
ARENA PHARMACEUTICALS INC COM 040047102 56 39,200 SH   DFND 1 0 39,200 0
ARENA PHARMACEUTICALS INC COM 040047102 2,610 1,838,291 SH   SOLE 1,838,291 0 0
AVIRAGEN THERAPEUTICS INC COM 053761102 46 37,500 SH   DFND 1 0 37,500 0
AVIRAGEN THERAPEUTICS INC COM 053761102 2,137 1,737,376 SH   SOLE 1,737,376 0 0
CENTENE CORP DEL COM 15135B101 8,109 143,500 SH   SOLE 143,500 0 0
CENTENE CORP DEL COM 15135B101 175 3,100 SH   DFND 1 0 3,100 0
CONCERT PHARMACEUTICALS INC COM 206022105 86 8,400 SH   DFND 1 0 8,400 0
CONCERT PHARMACEUTICALS INC COM 206022105 4,036 392,188 SH   SOLE 392,188 0 0
CORIUM INTL INC COM 21887L107 134 32,958 SH   DFND 1 0 32,958 0
CORIUM INTL INC COM 21887L107 6,268 1,543,808 SH   SOLE 1,543,808 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 95 7,600 SH   DFND 1 0 7,600 0
ESPERION THERAPEUTICS INC NE COM 29664W105 4,462 356,400 SH   SOLE 356,400 0 0
EXPRESS SCRIPTS HLDG CO COM 30219G108 640 9,300 SH   DFND 1 0 9,300 0
EXPRESS SCRIPTS HLDG CO COM 30219G108 30,109 437,701 SH   SOLE 437,701 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 128 11,527 SH   DFND 1 0 11,527 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 5,988 539,470 SH   SOLE 539,470 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 252 25,500 SH   DFND 1 0 25,500 0
HALOZYME THERAPEUTICS INC COM 40637H109 11,855 1,199,944 SH   SOLE 1,199,944 0 0
HEALTHWAYS INC COM 422245100 8,536 375,200 SH   SOLE 375,200 0 0
HEALTHWAYS INC COM 422245100 182 8,000 SH   DFND 1 0 8,000 0
INOTEK PHARMACEUTICALS CORP COM 45780V102 53 8,700 SH   DFND 1 0 8,700 0
INOTEK PHARMACEUTICALS CORP COM 45780V102 2,463 403,722 SH   SOLE 403,722 0 0
LILLY ELI & CO COM 532457108 838 11,400 SH   DFND 1 0 11,400 0
LILLY ELI & CO COM 532457108 39,423 536,005 SH   SOLE 536,005 0 0
MALLINCKRODT PUB LTD CO SHS G5785G107 319 6,400 SH   DFND 1 0 6,400 0
MALLINCKRODT PUB LTD CO SHS G5785G107 14,951 300,100 SH   SOLE 300,100 0 0
MIMEDX GROUP INC COM 602496101 230 26,000 SH   DFND 1 0 26,000 0
MIMEDX GROUP INC COM 602496101 10,805 1,219,550 SH   SOLE 1,219,550 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 167 11,100 SH   DFND 1 0 11,100 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 7,838 520,798 SH   SOLE 520,798 0 0
MYRIAD GENETICS INC COM 62855J104 172 10,300 SH   DFND 1 0 10,300 0
MYRIAD GENETICS INC COM 62855J104 8,082 484,800 SH   SOLE 484,800 0 0
NEURODERM LTD ORD SHS M74231107 87 3,900 SH   DFND 1 0 3,900 0
NEURODERM LTD ORD SHS M74231107 4,060 182,900 SH   SOLE 182,900 0 0
ORTHOFIX INTL N V COM N6748L102 3,943 108,975 SH   SOLE 108,975 0 0
ORTHOFIX INTL N V COM N6748L102 87 2,400 SH   DFND 1 0 2,400 0
PARATEK PHARMACEUTICALS INC COM 699374302 40 2,600 SH   DFND 1 0 2,600 0
PARATEK PHARMACEUTICALS INC COM 699374302 1,878 121,919 SH   SOLE 121,919 0 0
RETROPHIN INC COM 761299106 195 10,300 SH   DFND 1 0 10,300 0
RETROPHIN INC COM 761299106 9,135 482,589 SH   SOLE 482,589 0 0
SANOFI SPONSORED ADR 80105N105 1,043 25,800 SH   DFND 1 0 25,800 0
SANOFI SPONSORED ADR 80105N105 48,868 1,208,400 SH   SOLE 1,208,400 0 0
SHIRE PLC SPONSORED ADR 82481R106 699 4,100 SH   DFND 1 0 4,100 0
SHIRE PLC SPONSORED ADR 82481R106 32,764 192,300 SH   SOLE 192,300 0 0
TESARO INC COM 881569107 403 3,000 SH   DFND 1 0 3,000 0
TESARO INC COM 881569107 18,733 139,300 SH   SOLE 139,300 0 0
ZOGENIX INC COM NEW 98978L204 1,881 154,800 SH   SOLE 154,800 0 0
ZOGENIX INC COM NEW 98978L204 40 3,300 SH   DFND 1 0 3,300 0