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Stockholders' Equity (Tables)
3 Months Ended
Mar. 31, 2022
Equity [Abstract]  
Summary of Stock Option Activity

The following table sets forth the stock option activity for the three months ended March 31, 2022:

 

 

 

​Number
of shares

 

 

​Weighted
average
exercise price

 

 

Weighted
average
contractual
term

 

 

​Aggregate
intrinsic
value

 

Outstanding at December 31, 2021

 

 

5,090,377

 

 

$

28.89

 

 

 

 

 

 

 

Granted

 

 

1,223,019

 

 

 

30.05

 

 

 

 

 

 

 

Exercised

 

 

(18,015

)

 

 

10.08

 

 

 

 

 

 

 

Forfeited

 

 

(67,139

)

 

 

43.83

 

 

 

 

 

 

 

Expired

 

 

(9,212

)

 

 

53.10

 

 

 

 

 

 

 

Outstanding at March 31, 2022

 

 

6,219,030

 

 

$

28.98

 

 

 

7.6

 

 

$

106,188,389

 

Vested and expected to vest at March 31, 2022

 

 

6,219,030

 

 

$

28.98

 

 

 

7.6

 

 

$

106,188,389

 

Exercisable at March 31, 2022

 

 

2,932,835

 

 

$

15.85

 

 

 

5.7

 

 

$

82,434,018

 

Schedule of RSU Activity

The following table sets forth the RSU activity for the three months ended March 31, 2022:

 

 

Number
of shares

 

 

Weighted
average
grant date
fair value

 

Outstanding at December 31, 2021

 

 

302,764

 

 

$

42.93

 

Granted

 

 

429,902

 

 

 

23.27

 

Vested

 

 

(61,581

)

 

 

41.49

 

Forfeited

 

 

(3,719

)

 

 

48.73

 

Outstanding at March 31, 2022

 

 

667,366

 

 

$

30.36

 

Schedule of Stock-Based Compensation Expense Recognized

Stock-based compensation expense recognized for the three months ended March 31, 2022 and 2021 was allocated as follows:

 

 

Three Months Ended March 31,

 

 

2022

 

 

2021

 

Research and development

 

$

1,809,477

 

 

$

1,534,395

 

General and administrative

 

 

5,788,852

 

 

 

2,196,702

 

Total

 

$

7,598,329

 

 

$

3,731,097

 

Schedule of Warrant Activity

The following table summarizes warrant activity for the three months ended March 31, 2022:

 

 

 

 

 

 

Weighted

 

 

 

 

 

 

average

 

 

 

Warrants

 

 

exercise price

 

Outstanding at December 31, 2021

 

 

15,541

 

 

$

80.43

 

Issued

 

 

 

 

 

 

Exercised

 

 

 

 

 

 

Outstanding at March 31, 2022

 

 

15,541

 

 

$

80.43