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Stockholders' Equity - Additional Information (Details)
1 Months Ended 3 Months Ended 9 Months Ended
Dec. 05, 2019
USD ($)
Dec. 31, 2019
USD ($)
$ / shares
shares
May 31, 2019
USD ($)
Sep. 30, 2021
USD ($)
$ / shares
shares
Sep. 30, 2021
USD ($)
Vote
d
$ / shares
shares
Sep. 30, 2020
USD ($)
shares
Dec. 31, 2020
$ / shares
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Common stock, voting right per share | Vote         1    
Weighted average grant date fair value | $ / shares         $ 45.81    
Unrecognized compensation cost related to non-vested stock options expected to be recognized       $ 60,400,000 $ 60,400,000    
Expected vesting period for non-vested share-based compensation         3 years 2 months 12 days    
Non-vested options outstanding | shares       6,169 6,169    
Exercise price of warrants (in dollars per share) | $ / shares       $ 80.43 $ 80.43   $ 80.43
Warrants | Term loan 2020 tranche one              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Common stock to be issued if warrants are exercised (in shares) | shares       15,541 15,541    
Exercise price of warrants (in dollars per share) | $ / shares       $ 80.43 $ 80.43    
Trading days | d         10    
Term of warrants (in years)         7 years    
Fair value       $ 900,000 $ 900,000    
Restricted Stock Units              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Vesting period         4 years    
Compensation cost not yet recognized related to unvested RSUs       $ 10,800,000 $ 10,800,000    
Weighted average contractual term         3 years 2 months 12 days    
2015 Plan              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Shares available for future grant | shares       4,410,279 4,410,279    
Underwritten Public Offering              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Proceeds from issuance of common stock, gross   $ 200,100,000          
Shares issued | shares   2,300,000          
Proceeds from issuance of common stock, net   $ 187,100,000          
Share Price | $ / shares   $ 87.00          
2019 Shelf Registration              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Proceeds from issuance of common stock, gross $ 229,300,000            
SVB Leerink              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Common stock sales agreement, commission percentage     3.00%        
Common stock sales agreement, shares unsold amount     $ 29,900,000        
SVB Leerink | December 2019 Sales Agreement              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Common stock sales agreement, commission percentage   3.00%          
Proceeds from issuance of common stock, gross         $ 7,400,000 $ 12,400,000  
Shares issued | shares       0 110,296 141,678  
Proceeds from issuance of common stock, net         $ 7,200,000 $ 12,100,000  
Maximum | SVB Leerink              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Common stock sales agreement, authorized amount     $ 50,000,000        
Maximum | SVB Leerink | December 2019 Sales Agreement              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Common stock sales agreement, authorized amount   $ 80,000,000