POWER OF ATTORNEY

I hereby constitute and appoint each of Maiken Keson-Brookes and Christian
Klemt, signing singly, my true and lawful attorney-in-fact to:

(1)	execute on my behalf any Form 3,Initial Statement of Beneficial Ownership of
Securities, Form 4,Statement of Changes of Beneficial Ownership of Securities,
or Form 5,Annual Statement of Beneficial Ownership of Securities, including any
amendments, supplements or exhibits thereto (each, a "Section 16 Report"), which
I am required to file in my capacity as an officer, director or owner of greater
than 10% of the outstanding shares of uniQure N.V. (the "Company") in accordance
with Section 16(a) of the Securities Exchange Act of 1934, as amended (the
"Act") and the rules thereunder;

(2)	do and perform any and all acts for and on my behalf that may be necessary
or desirable to complete and execute any Section 16 Report and timely file such
report with the United States Securities and Exchange Commission and any stock
exchange or similar authority;

(3)	seek or obtain, as my representative and on my behalf, information on
transactions in the Company's securities from any third party, including
brokers, employee benefit plan administrators and trustees, and I hereby
authorize any such third party to release any such information to each of my
attorneys in fact appointed by this Power of Attorney; and

(4)	take any other action of any type whatsoever in connection with the
foregoing which, in the opinion of such attorney in fact, may be to my benefit,
in my best interest, or that I am legally required to do, it being understood
that the documents executed by such attorney in fact on my behalf pursuant to
this Power of Attorney shall be in such form and shall contain such terms and
conditions as such attorney in fact may approve in such attorney-in-fact's
discretion.

I hereby grant to each attorney in fact hereunder full power and authority to do
and perform any and every act and thing whatsoever necessary or desirable to be
done in the exercise of any of the rights and powers herein granted, as fully to
all intents and purposes as I might or could do if personally present, with full
power of substitution or revocation, hereby ratifying and confirming all that
such attorney in fact, or such attorney in fact's substitute or substitutes,
shall lawfully do or cause to be done by virtue of this Power of Attorney and
the rights and powers herein granted.

I acknowledge that this Power of Attorney does not relieve me of my
responsibilities to comply with Section 16 of the Act and the attorneys-in-fact,
in serving in such capacity at my request, are not assuming, nor is the Company
assuming, any of my responsibilities to comply with Section 16 of the Act.

This Power of Attorney shall remain in full force and effect until I am no
longer required to file Section 16 Reports with respect to my holdings of and
transactions in Company securities, unless I earlier revoke it in a signed
writing delivered to the attorneys in fact.

IN WITNESS WHEREOF, I have caused this Power of Attorney to be executed as of
this 1st day of June, 2017.

By:  /s/ Steven Zelenkofske

Print Name: Steven Zelenkofske