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Share-Based Compensation - Share-based compensation expense (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Sep. 30, 2021
Sep. 30, 2020
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]        
Total share-based compensation $ (12,822) $ (6,457) $ (30,808) $ (21,392)
Total equity awards compensation expense (13,289) (6,803) (32,174) (22,465)
R&D        
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]        
Total share-based compensation (4,858) (3,333) (11,572) (7,771)
Total equity awards compensation expense (4,858) (3,333) (11,572) (7,771)
S&O        
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]        
Total share-based compensation (3,876) (3,190) (9,266) (8,380)
Total equity awards compensation expense (3,876) (3,190) (9,266) (8,380)
G&A        
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]        
Total share-based compensation (4,088) 66 (9,970) (5,241)
Total equity awards compensation expense (4,555) (280) (11,336) (6,314)
RSU        
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]        
Total share-based compensation (12,607) (6,885) (30,000) (21,031)
RSU | R&D        
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]        
Total share-based compensation (4,858) (3,333) (11,572) (7,771)
RSU | S&O        
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]        
Total share-based compensation (3,818) (2,957) (9,026) (8,092)
RSU | G&A        
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]        
Total share-based compensation (3,931) (595) (9,402) (5,168)
OSA/BSPCE        
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]        
Total share-based compensation (215) 428 (808) (361)
OSA/BSPCE | R&D        
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]        
Total share-based compensation 0 0 0 0
OSA/BSPCE | S&O        
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]        
Total share-based compensation (58) (233) (240) (288)
OSA/BSPCE | G&A        
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]        
Total share-based compensation (157) 661 (568) (73)
BSA        
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]        
BSAs (467) (346) (1,366) (1,073)
BSA | R&D        
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]        
BSAs 0 0 0 0
BSA | S&O        
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]        
BSAs 0 0 0 0
BSA | G&A        
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]        
BSAs $ (467) $ (346) $ (1,366) $ (1,073)