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Nature of Expenses Allocated by Function - Research and Development (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Condensed Income Statements, Captions [Line Items]      
Personnel expenses $ (451,428) $ (445,563) $ (332,353)
Personnel expense excluding equity awards compensation expense and research tax credit (296,336) (284,015) (220,317)
Equity awards compensation expense (66,600) (71,612) (43,259)
Research tax credit 10,687 6,289 4,941
Total research and development expenses (179,263) (173,925) (123,649)
Research and Development Expense      
Condensed Income Statements, Captions [Line Items]      
Personnel expenses (130,696) (125,662) (86,389)
Personnel expense excluding equity awards compensation expense and research tax credit (120,024) (110,939) (79,222)
Equity awards compensation expense (21,359) (21,012) (12,108)
Research tax credit 10,687 6,289 4,941
Other cash operating expenses (37,119) (34,073) (29,867)
Subcontracting and other headcount related costs (15,129) (19,437) (14,713)
Rent and facilities costs (14,201) (11,466) (10,939)
Consulting and professional fees (3,320) (2,680) (2,423)
Marketing costs (4,976) (909) (953)
Other 507 419 (839)
Other non-cash operating expenses (11,448) (14,190) (7,393)
Depreciation and amortization (10,602) (13,420) (7,211)
Net change in other provisions (846) (770) (182)
Total research and development expenses $ (179,263) $ (173,925) $ (123,649)