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Share-Based Compensation - Share-based compensation expense (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]        
Share-based compensation expense $ (17,051) $ (21,383) $ (55,267) $ (50,671)
Total equity awards compensation expense (17,262) (22,028) (56,333) (51,887)
R&D        
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]        
Share-based compensation expense (4,901) (6,361) (16,354) (14,738)
Total equity awards compensation expense (4,901) (6,361) (16,354) (14,738)
S&O        
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]        
Share-based compensation expense (6,952) (9,897) (22,848) (23,009)
Total equity awards compensation expense (6,952) (9,897) (22,848) (23,009)
G&A        
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]        
Share-based compensation expense (5,198) (5,125) (16,065) (12,924)
Total equity awards compensation expense (5,409) (5,770) (17,131) (14,140)
RSUs        
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]        
Share-based compensation expense (15,563) (19,781) (50,806) (45,825)
RSUs | R&D        
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]        
Share-based compensation expense (4,723) (5,929) (15,785) (13,443)
RSUs | S&O        
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]        
Share-based compensation expense (6,604) (9,896) (21,539) (23,028)
RSUs | G&A        
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]        
Share-based compensation expense (4,236) (3,956) (13,482) (9,354)
Share options / BSPCE        
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]        
Share-based compensation expense (1,488) (1,602) (4,461) (4,846)
Share options / BSPCE | R&D        
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]        
Share-based compensation expense (178) (432) (569) (1,295)
Share options / BSPCE | S&O        
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]        
Share-based compensation expense (348) (1) (1,309) 19
Share options / BSPCE | G&A        
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]        
Share-based compensation expense (962) (1,169) (2,583) (3,570)
BSAs        
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]        
Issuance of Stock and Warrants for services or claims (211) (645) (1,066) (1,216)
BSAs | R&D        
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]        
Issuance of Stock and Warrants for services or claims 0 0 0 0
BSAs | S&O        
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]        
Issuance of Stock and Warrants for services or claims 0 0 0 0
BSAs | G&A        
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]        
Issuance of Stock and Warrants for services or claims $ (211) $ (645) $ (1,066) $ (1,216)