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Net Loss Per Share Attributable to Guardant Health, Inc. Common Stockholders (Tables)
12 Months Ended
Dec. 31, 2021
Earnings Per Share [Abstract]  
Schedule of Earnings Per Share, Basic and Diluted
The following table sets forth the computation of the basic and diluted net loss per share attributable to Guardant Health, Inc. common stockholders:
Year Ended December 31,
202120202019
(in thousands, except per share data)
Net loss$(384,770)$(246,283)$(67,851)
Adjustment of redeemable noncontrolling interest
(20,900)(7,500)(7,800)
Net loss attributable to Guardant Health, Inc. common stockholders, basic and diluted
$(405,670)$(253,783)$(75,651)
Net loss per share attributable to Guardant Health, Inc. common stockholders, basic and diluted
$(4.00)$(2.60)$(0.84)
Weighted-average shares used in computing net loss per share attributable to Guardant Health, Inc. common stockholders, basic and diluted
101,314 97,504 90,597 
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share The following weighted-average common stock equivalents were excluded from the calculation of diluted net loss per share attributable to Guardant Health, Inc. common stockholders for the periods presented as they had an anti-dilutive effect:
Year Ended December 31,
202120202019
(in thousands)
Stock options issued and outstanding (1)
2,715 3,830 5,976 
Restricted stock units1,208 687 252 
MSUs2,357 2,031 — 
PSUs397 60 — 
ESPP obligation45 37 52 
Common stock subject to repurchase18 31 
Convertible senior notes8,225 961 — 
Total14,954 7,624 6,311 
(1)    Excludes stock options of 3,652,219 and 4,053,335 shares of the Joint Venture's Class B common stock granted under the AMEA 2020 Plan as of December 31, 2021 and 2020, respectively.