Summary of Stock Option Activity (Details) - Equity Option [Member] - USD ($)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Offsetting Assets [Line Items]
Number of options, outstanding, beginning balance	144,962	44,968
Weighted average exercise price, outstanding, beginning balance	$ 64.20	$ 231.90
weighted average remaining contractual term (years), outstanding, beginning balance		8 years 6 months 7 days
Aggregate intrinsic value outstanding beginning balance	$ 59,860
Number of Options, Granted	58,039	117,215
Weighted Average Exercise Price, Granted	$ 27.79	$ 30.42
Number of Options, Exercised		(1,125)
Weighted Average Exercise Price, Exercised	$ 83.78	$ 21.20
Aggregate intrinsic value, forfeited or expired		$ 9,550
Number of Options, Forfeited or expired	(6,995)	(16,096)
Weighted Average Exercise Price, Forfeited or Expired		$ 289.87
weighted average remaining contractual term (years), outstanding, beginning balance	8 years 9 months
Number of options, outstanding, ending balance	196,006	144,962
Weighted average exercise price, outstanding, ending balance	$ 52.72	$ 64.20
weighted average remaining contractual term (years), outstanding, ending balance	8 years 1 month 13 days
Aggregate intrinsic value outstanding ending balance		$ 59,860
Number of options, outstanding, exercisable	95,233
Weighted average exercise price, outstanding, exercisable	$ 78.20
weighted average remaining contractual term (years), exercisable	7 years 8 months 23 days
Aggregate intrinsic value, outstanding exercisable