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Warrants (Tables)
12 Months Ended
Dec. 31, 2018
Equity [Abstract]  
Summary of Common Stock Warrants Outstanding
A rollforward of the common stock warrants outstanding at December 31, 2018 is as follows.
 
 
 
 
Number of
Warrants
 
 
Weighted
Average
Exercise Price
 
 
Weighted
Average
Remaining
Contractual
Term (Years)
 
 
Aggregate
Intrinsic
Value
 
Outstanding January 1, 2018
 
 
328,444
 
 
$
77.90
 
 
 
 
 
 
$
 
Series A warrants issued
 
 
2,465,000
 
 
$
6.50
 
 
 
 
 
 
 
 
 
Series A warrants expired
 
 
(2,465,000
)
 
$
(6.50
)
 
 
 
 
 
 
 
 
Series B warrants issued
 
 
2,465,000
 
 
$
7.50
 
 
 
 
 
 
 
 
 
Pre-funded warrants issued
 
 
784,000
 
 
$
6.50
 
 
 
 
 
 
 
 
 
Pre-funded warrants exercised
 
 
(784,000
)
 
$
(6.50
)
 
 
 
 
 
 
 
 
Warrants issued
 
 
937,500
 
 
$
3.90
 
 
 
 
 
 
 
 
 
Pre-funded warrants issued
 
 
697,500
 
 
$
0.01
 
 
 
 
 
 
 
 
 
Outstanding December 31, 2018
 
 
4,428,444
 
 
$
10.78
 
 
 
4.30
 
 
$
 
Summary of the Warrants Outstanding
The following represents a summary of the warrants outstanding at each of the dates identified:
 
           
Number of Shares
Underlying Warrants
 
           
For the Year Ended
December 31,
 
Issue Date
 
Classification
  
Exercise
Price
  
Expiration
Date
  
2018
  
2017
 
December 3, 2018
  Equity  $3.90   June 3, 2024   937,500    
December 3, 2018
  Equity  $3.20   Prefunded   697,500    
April 3, 2018
  Equity  $7.50   April 3, 2023   2,407,500    
April 4, 2018
  Equity  $7.50   April 4, 2023   57,500    
June 15, 2015
  Equity  $75.50   June 15, 2020   319,003   319,003 
June 15, 2015
  Equity  $83.50   June 16, 2020   2,515   2,515 
August 31, 2015
  Equity  $118.00   August 31, 2020   3,000   3,000 
March 21, 2014
  Equity  $226.60   March 21, 2019   3,710   3,710 
March 21, 2014
  Equity  $226.60   March 21, 2019   216   216