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Term Loans - Oxford Term Loans (Details)
1 Months Ended 12 Months Ended
Jan. 04, 2021
USD ($)
Mar. 15, 2019
USD ($)
advance
Jan. 31, 2021
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Debt Instrument [Line Items]          
Loss from extinguishment of debts, net       $ 968,000 $ 0
Term Loan Facility          
Debt Instrument [Line Items]          
Percentage of final payment of full principal amount   5.50%      
Prepayment fee percentage, year two   2.00%      
Prepayment fee percentage, thereafter   1.00%      
Oxford Term Loans          
Debt Instrument [Line Items]          
Debt discount   $ 1,094,000      
Debt issuance costs   2,205,000      
Interest rate, effective percentage         11.60%
Oxford Term Loan Facility          
Debt Instrument [Line Items]          
Repayments of long-term lines of credit $ 76,447,000   $ 76,447,000    
Debt instrument fee amount comprised 4,300,000        
Debt instrument of principal amount payment 2,800,000        
Debt instrument prepayment fee amount 1,500,000        
Loss from extinguishment of debts, net $ 1,939,000        
Term Loan          
Debt Instrument [Line Items]          
Contingent promissory note payable   $ 100,000,000      
Number of advances | advance   2      
Interest rate on debt   9.50%      
Period of interest only payments   36 months      
Amortization period   23 months      
Term Loan | LIBOR          
Debt Instrument [Line Items]          
Basis spread on variable rate   7.00%      
Term Loan | First tranche          
Debt Instrument [Line Items]          
Contingent promissory note payable   $ 75,000,000      
Term Loan | Term Loan Facility, Tranche Two          
Debt Instrument [Line Items]          
Contingent promissory note payable   $ 25,000,000