Exhibit 32.1

CERTIFICATIONS UNDER SECTION 906

Pursuant to section 906 of the Sarbanes-Oxley Act of 2002 (subsections (a) and (b) of section 1350, chapter 63 of title 18, United States Code), each of the undersigned officers of Intra-Cellular Therapies, Inc., a Delaware corporation (the “Company”), does hereby certify, to such officer’s knowledge, that:

The Annual Report for the year ended December 31, 2022 (the “Form 10-K”) of the Company fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, and the information contained in the Form 10-K fairly presents, in all material respects, the financial condition and results of operations of the Company.

Dated: March 1, 2023	/s/ Sharon Mates, Ph.D.
	Sharon Mates, Ph.D.
	Chairman, President and Chief Executive Officer (principal executive officer)
Dated: March 1, 2023	/s/ Lawrence J. Hineline
	Lawrence J. Hineline
	Senior Vice President of Finance and Chief Financial Officer (principal financial officer and principal accounting officer)