Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the reference to our firm under the caption “Experts” and to the use of our report dated June 19, 2013, in the Registration Statement (Form S-1 No. 333-00000) and related Prospectus of Intra-Cellular Therapies, Inc. for the registration of 000,000 shares of its common stock.

/s/ Ernst & Young LLP

McLean, VA

January 10, 2014