March 16, 2016

Via EDGAR

United States Securities and Exchange Commission

Division of Corporation Finance

100 F Street NE

Washington, DC 20549

Attn: Suzanne Hayes, Division of Corporate Finance

RE: Alcobra Ltd.

Registration Statement on Form F-3

Filed on March 4, 2016

File No. 333-209960

Ladies and Gentlemen:

Alcobra Ltd. (“Alcobra”) hereby requests acceleration of the effectiveness of the above-referenced registration statement pursuant to Rule 460 and Rule 461 under the Securities Act of 1933, as amended (the “Securities Act”), so that it may become effective on March 18, 2016, at 9 a.m., Eastern Time, or as soon thereafter as is practicable.

Alcobra acknowledges that:

· should the Commission or the staff, acting pursuant to delegated authority, declare the above-referenced registration statement effective, it does not foreclose the Commission from taking any action with respect to the above-referenced registration statement;

· the action of the Commission or the staff, acting pursuant to delegated authority, in declaring the above-referenced registration statement effective, does not relieve Alcobra from its full responsibility for the adequacy and accuracy of the disclosure in the above-referenced registration statement; and

· Alcobra may not assert staff comments and the declaration of effectiveness as a defense in any proceeding initiated by the Commission or any person under the federal securities laws of the United States.

Alcobra understands that the Commission will consider this request for acceleration of the effective date of this above-referenced registration statement as a confirmation of the fact that Alcobra is aware of its respective responsibilities under the Securities Act and the Securities Exchange Act of 1934, as amended, as they relate to the proposed public offering of the securities specified in the referenced above registration statement.

Very truly yours,

/s/ Dr. Tomer Berkovitz

Dr. Tomer Berkovitz

Chief Financial Officer and
Chief Operating Officer

Cc: Shy S. Baranov, Esq.