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Income Taxes - Reconciliation (Details)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Income Taxes    
Computed "expected" income tax benefit, percent 21.00% 21.00%
State income tax benefit, net of federal income tax benefit, percent 6.30% 6.30%
Permanent items, primarily change in fair value of warrants and non-deductible share-based compensation 1.00% 2.60%
Tax credits, percent (2.10%) (0.70%)
Stock-option cancellations, percent (0.20%) (8.20%)
Change in valuation allowance, percent (26.00%) (21.00%)