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Income Taxes - Reconciliation of Income Taxes Computed at Federal Statutory Rate and Provision for Income Taxes (Detail)
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Income Tax Disclosure [Abstract]      
Expected income tax 34.00% 34.00% 34.00%
State taxes, net of federal benefit (0.10%) (0.10%) (0.10%)
Permanent differences (1.40%) (3.00%) (0.50%)
Federal research and development credit 2.40% 0.60% 0.80%
Foreign rate differential (3.00%) (3.30%) 0.20%
Change in valuation allowance (31.90%) (29.90%) (35.60%)
Other 0.10% 0.70%  
Total income tax benefit (expense) 0.10% (1.00%) (1.20%)