Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Total revenue	$ 4,019	$ 1,312	$ 6,188	$ 2,465
Operating expenses:
Research and development	56,011	31,569	100,767	58,831
General and administrative	14,512	12,952	28,250	24,787
Total operating expenses	70,523	44,521	129,017	83,618
Loss from operations	(66,504)	(43,209)	(122,829)	(81,153)
Other income (expense):
Interest income	7,700	639	14,390	692
Other expense, net	(97)	(2)	(238)	(72)
Total other income, net	7,603	637	14,152	620
Loss before income taxes	(58,901)	(42,572)	(108,677)	(80,533)
Benefit from income taxes	(4,306)	(1,328)	(7,218)	(2,999)
Net loss	$ (54,595)	$ (41,244)	$ (101,459)	$ (77,534)
Basic (in dollars per share)	$ (1.03)	$ (0.88)	$ (1.92)	$ (1.66)
Diluted (in dollars per share)	$ (1.03)	$ (0.88)	$ (1.92)	$ (1.66)
Weighted-average ordinary shares outstanding used in per share calculations- basic (in shares)	53,121	46,805	52,812	46,755
Weighted-average ordinary shares outstanding used in per share calculations- diluted (in shares)	53,121	46,805	52,812	46,755
Collaboration revenue
Total revenue	$ 4,019	$ 1,312	$ 6,138	$ 2,415
Revenue from license and intellectual property
Total revenue	$ 0	$ 0	$ 50	$ 50