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Income Taxes (Tables)
12 Months Ended
Dec. 31, 2022
Income Tax Disclosure [Abstract]  
Income (Loss) Before Provision for Income Taxes by Country Income (loss) before provision for income taxes by country for each of the fiscal periods presented is summarized as follows (in thousands):
Year Ended 
December 31,
202220212020
Ireland$(119,571)$65,456 $(116,981)
Switzerland— — 
U.S.(6,034)6,465 5,546 
Income (loss) before provision for income taxes$(125,605)$71,921 $(111,427)
Components of the Provision for Income Taxes
Components of the provision for income taxes for each of the fiscal periods presented consisted of the following (in thousands):
Year Ended 
December 31,
202220212020
Current:
U.S. Federal$2,422 $356 $1,402 
U.S. State 55 16 
Switzerland— — 
Ireland— — — 
Total current provision$2,477 $372 $1,405 
Deferred:
U.S. Federal$(11,039)$4,581 $(1,688)
U.S. State (94)(7)— 
Switzerland— — — 
Ireland— — — 
Total deferred benefit$(11,133)$4,574 $(1,688)
Provision for (benefit from) income taxes$(8,656)$4,946 $(283)
Reconciliation Between Income Taxes Computed at the Standard Irish Statutory Tax Rate and the Provision for income Taxes Following is a reconciliation between income taxes computed at the Irish statutory tax rate and the provision for income taxes for each of the fiscal periods presented (in thousands):
Year Ended 
December 31,
 202220212020
Taxes at the Irish statutory tax rate of 12.5%$(15,700)$8,990 $(13,928)
Income tax at rates other than applicable statutory rate(2,338)(398)(3,402)
Change in valuation allowance22,681 4,108 16,266 
Share-based payments518 5,173 3,409 
Tax credits(8,949)(5,355)(2,786)
Income not subject to tax(5,000)(7,587)— 
Other132 15 158 
Provision for (benefit from) income taxes$(8,656)$4,946 $(283)
Significant Components of Net Deferred Tax Assets
Significant components of the Company’s net deferred tax assets as of December 31, 2022, and 2021 are as follows (in thousands):
December 31,
20222021
Deferred tax assets:
Net operating loss carryforwards$136,487 $115,424 
Tax credits23,193 17,552 
Lease liability1,398 2,670 
Accruals and other1,587 1,017 
Capitalized R&D10,544 — 
Share-based compensation7,628 7,114 
Gross deferred tax assets180,837 143,777 
Valuation allowance(161,098)(133,845)
Net deferred tax assets19,739 9,932 
Deferred tax liability:
Operating lease right-of-use assets(1,355)(2,626)
Fixed Assets(180)(235)
Net deferred tax assets$18,204 $7,071 
Summary of Income Tax Contingencies
A reconciliation of the beginning and ending amounts of unrecognized tax benefits is as follows (in thousands):
20222021
Gross Unrecognized Tax Benefits at January 1$8,329 $7,252 
Additions for tax positions taken in the current year2,243 1,342 
Additions for tax positions taken in the prior year992 — 
Reductions for tax positions taken in the prior year — (265)
Gross Unrecognized Tax Benefits at December 31 $11,564 $8,329