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Net Income (Loss) Per Ordinary Share (Tables)
3 Months Ended
Mar. 31, 2022
Earnings Per Share [Abstract]  
Calculation of Basic and Diluted Net Income (Loss) Per Ordinary Share
Net income (loss) per ordinary share was determined as follows (in thousands, except per share amounts):
Three Months Ended 
March 31,
20222021
Numerator:
Net loss$(36,290)$(36,735)
Denominator:
Weighted-average ordinary shares outstanding 46,704 40,250 
Net loss per ordinary share:
Basic and diluted net loss per share$(0.78)$(0.91)
Ordinary Shares Equivalent Not Included in Diluted Net Income (Loss) Per Ordinary Share
The equivalent ordinary shares not included in diluted net income (loss) per share because their effect would be anti-dilutive are as follows (in thousands):
 Three Months Ended 
March 31,
20222021
Stock options to purchase ordinary shares10,319 8,825