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Share-based Compensation - Share-based Compensation Plan - Option Activity (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Feb. 12, 2021
Mar. 31, 2021
Dec. 31, 2020
Options      
Options, outstanding beginning balance (in shares)   8,744,765  
Options, granted (in shares) 1,372,587 2,550,977  
Options, exercised (in shares)   (229,379)  
Options, forfeited (in shares)   (236,876)  
Options, expired (in shares)   (2,003,988)  
Options, outstanding ending balance (in shares)   8,825,499 8,744,765
Options, vested and expected to vest ending balance (in shares)   8,290,411  
Options, Vested (in shares)   3,356,692  
Weighted Average Exercise Price      
Weighted average exercise price, outstanding beginning balance (in dollars per share)   $ 20.42  
Weighted average exercise price, granted (in dollars per share) $ 22.85 22.39  
Weighted average exercise price, exercised (in dollars per share)   13.43  
Weighted average exercise price, forfeited (in dollars per share)   30.60  
Weighted average exercise price, expired (in dollars per share)   40.98  
Weighted average exercise price, outstanding ending balance (in dollars per share)   16.23 $ 20.42
Weighted average exercise price, vested and expected to vest, ending balance (in dollars per share)   16.15  
Weighted Average Exercise Price, vested (in dollars per shares)   $ 14.60  
Options, Additional Disclosures      
Weighted average remaining contractual term, outstanding (in years)   7 years 5 months 8 days 7 years 2 months 8 days
Weighted average remaining contractual term, vested and expected to vest (in years)   7 years 4 months 13 days  
Weighted Average Remaining Contractual Term, vested (in years)   6 years 5 months 23 days  
Aggregate intrinsic value, outstanding   $ 81,230 $ 4,656
Aggregate intrinsic value, vested and expected to vest, ending balance   77,128  
Aggregate intrinsic value, vested   $ 37,958  
Unvested options, forfeited (in shares) 179,959    
Unvested options, expired (in shares) 1,934,446