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Net Loss Per Ordinary Share - Calculation of Basic and Diluted Net Income or Loss Per Share (Detail) - USD ($)
$ / shares in Units, shares in Thousands, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2019
Sep. 30, 2019
Jun. 30, 2019
Mar. 31, 2019
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Numerator:                      
Net income (loss) $ (21,554) $ (19,448) $ (15,810) $ (20,865) $ (22,461) $ (24,559) $ (59,882) $ (48,743) $ (77,677) $ (155,645) $ (153,237)
Denominator:                      
Weighted-average ordinary shares outstanding (in shares)                 39,882 39,559 37,654
Basic and diluted net loss per share (in dollars per share)                 $ (1.95) $ (3.93) $ (4.07)