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Significant Agreements - Celgene Collaboration Agreement (Details)
$ / shares in Units, $ in Millions
Mar. 20, 2018
USD ($)
agreement_term
$ / shares
shares
Collaboration Program, US Rights [Member]  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]  
Collaboration Agreement, Potential Regulatory Milestone Payments Per Program $ 90.0
Collaboration Agreement, Potential Commercial Milestone Payments Per Program 375.0
Collaboration Program, Global Rights [Member]  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]  
Collaboration Agreement, Potential Regulatory Milestone Payments Per Program 187.5
Collaboration Agreement, Potential Commercial Milestone Payments Per Program 375.0
Celgene [Member]  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]  
Collaboration Agreement, Upfront Payment $ 100.0
Collaboration Agreement, Upfront Payment, Payment Term 10 days
Collaboration Agreement, Option Fees and Milestone Payments, Payment Term 30 days
Collaboration Agreement, Potential Regulatory and Commercial Milestone Payments Per Program $ 562.5
Collaboration Agreement, Term of Agreement 6 years
Collaboration Agreement, Number of Additional 12 Month Period Extension Allowed | agreement_term 2
Collaboration Agreement, Extension Fee per Extension Period $ 10.0
Celgene [Member] | Collaboration Program, US Rights [Member]  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]  
Collaboration Agreement, Exercise Fee per Program 80.0
Celgene [Member] | Collaboration Program, Global Rights [Member]  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]  
Collaboration Agreement, Exercise Fee per Program $ 55.0
Celgene [Member] | Private Placement [Member]  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]  
Share Subscription Agreement, Number of Ordinary Shares Issued in Transaction | shares 1,174,536
Share Subscription Agreement, Price Per Share | $ / shares $ 42.57
Share Subscription Agreement, Consideration Received on Transaction $ 50.0
Share Subscription Agreement, Premium Received on Transaction 10.2
Collaborative Arrangement [Member] | Celgene [Member]  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]  
Collaboration Agreement, Initial Transaction Price $ 110.2