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Net Loss Per Ordinary Share (Tables)
9 Months Ended
Sep. 30, 2018
Earnings Per Share [Abstract]  
Calculation of Basic and Diluted Net Income or Loss Per Ordinary Share
Net loss per ordinary share was determined as follows (in thousands, except per share amounts):
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2018
 
2017
 
2018
 
2017
Numerator:
 
 
 
 
 
 
 
Net loss
$
(24,559
)
 
$
(52,394
)
 
$
(133,184
)
 
$
(105,479
)
Denominator:
 
 
 
 
 
 
 
Weighted-average ordinary shares outstanding
39,850

 
38,292

 
39,457

 
37,384

Net loss per share:
 
 
 
 
 
 
 
Basic and diluted net loss per share
$
(0.62
)
 
$
(1.37
)
 
$
(3.38
)
 
$
(2.82
)
Ordinary Shares Equivalent Not Included in Diluted Net Loss Per Share
The equivalent ordinary shares not included in diluted net loss per share because their effect would be anti-dilutive are as follows (in thousands):
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2018
 
2017
 
2018
 
2017
Stock options to purchase ordinary shares
7,253

 
4,387

 
7,253

 
4,387